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PCT1 choline-phosphate cytidylyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853116, updated on 5-May-2024

Summary

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Gene symbol
PCT1
Gene description
choline-phosphate cytidylyltransferase
Primary source
SGD:S000003434
Locus tag
YGR202C
See related
AllianceGenome:SGD:S000003434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
BSR2; CCT1
Summary
Enables choline-phosphate cytidylyltransferase activity. Involved in CDP-choline pathway. Located in nuclear envelope. Part of NLS-dependent protein nuclear import complex. Human ortholog(s) of this gene implicated in spondylometaphyseal dysplasia with cone-rod dystrophy. Orthologous to several human genes including PCYT1A (phosphate cytidylyltransferase 1A, choline). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VII
Exon count:
1
Sequence:
Chromosome: VII; NC_001139.9 (903474..904748, complement)

Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Elongator subunit ELP2 Neighboring gene uncharacterized protein Neighboring gene phosphatase YCH1 Neighboring gene trifunctional formate-tetrahydrofolate ligase/methenyltetrahydrofolate cyclohydrolase/methylenetetrahydrofolate dehydrogenase ADE3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cessation of growth to prevent cell death due to inhibition of phosphatidylcholine synthesis is impaired at 37 degrees C in Saccharomyces cerevisiae. Howe AG, et al. J Biol Chem, 2002 Nov 15. PMID 12200438
  2. Purification and kinetic characterization of CTP:phosphocholine cytidylyltransferase from Saccharomyces cerevisiae. Friesen JA, et al. Protein Expr Purif, 2001 Feb. PMID 11162399
  3. Molecular cloning and characterization of the gene encoding cholinephosphate cytidylyltransferase in Saccharomyces cerevisiae. Tsukagoshi Y, et al. Eur J Biochem, 1987 Dec 15. PMID 2826147
  4. Expression in Escherichia coli of the Saccharomyces cerevisiae CCT gene encoding cholinephosphate cytidylyltransferase. Tsukagoshi Y, et al. J Bacteriol, 1991 Mar. PMID 1848222, Free PMC Article
  5. Comparison of the lipid regulation of yeast and rat CTP: phosphocholine cytidylyltransferase expressed in COS cells. Johnson JE, et al. Biochem J, 1992 Aug 1. PMID 1323275, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Pct1 interacts with Kap60 and Kap95 with this tripartite complex transiting the nuclear pore.
    Title: The Kap60-Kap95 karyopherin complex directly regulates phosphatidylcholine synthesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables choline-phosphate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline-phosphate cytidylyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables choline-phosphate cytidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in CDP-choline pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in CDP-choline pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylcholine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of NLS-dependent protein nuclear import complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
choline-phosphate cytidylyltransferase
NP_011718.1
  • Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; controls phosphatidylcholine homeostasis; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001139.9 Reference assembly

    Range
    903474..904748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181331.1 → NP_011718.1  TPA: choline-phosphate cytidylyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011718.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VUY4, P13259
    UniProtKB/TrEMBL
    A0A8H4C1V9, B3LI35, C7GRN4, C8Z994, G2WET0, N1P9Y2
    Conserved Domains (1) summary
    cd02174
    Location:102 → 251
    CCT; CTP:phosphocholine cytidylyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13259.2

Gene LinkOut

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