YTA7 Yta7p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: YTA7
Gene description: Yta7p
Primary source: FungiDB:YGR270W
Locus tag: YGR270W
See related: SGD:S000003502; AllianceGenome:SGD:S000003502
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables ATP hydrolysis activity; chromatin binding activity; and histone binding activity. Involved in negative regulation of transcription by RNA polymerase II; positive regulation of invasive growth in response to glucose limitation; and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleus. Is extrinsic component of endoplasmic reticulum membrane. Used to study breast cancer and prostate cancer. Orthologous to human ATAD2 (ATPase family AAA domain containing 2) and ATAD2B (ATPase family AAA domain containing 2B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See YTA7 in Genome Data Viewer

Location:: chromosome: VII

Exon count:: 1

Sequence:: Chromosome: VII; NC_001139.9 (1027370..1031509)

Chromosome VII - NC_001139.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001139.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Saccharomyces cerevisiae Yta7 ATPase hexamer contains a unique bromodomain tier that functions in nucleosome disassembly.
Title: The Saccharomyces cerevisiae Yta7 ATPase hexamer contains a unique bromodomain tier that functions in nucleosome disassembly.
this study identified the AAA+ ATPase Yta7/ATAD2 as a deposition factor for CENP-A at centromeres in yeast.
Title: The ATAD2/ANCCA homolog Yta7 cooperates with Scm3(HJURP) to deposit Cse4(CENP-A) at the centromere in yeast.
Data highlight the implication of Yta7 not only in gene expression, as expected, but also in genome organization, as a possible histone chaperone acting at boundary sites and regulating transcription. [review]
Title: Lessons from yeast on emerging roles of the ATAD2 protein family in gene regulation and genome organization.
Yta7 functions in both Rtt106-dependent and Rtt106-independent ways to modulate nucleosome spacing within genes.
Title: Maintenance of nucleosomal balance in cis by conserved AAA-ATPase Yta7.
Results suggested a direct role for Yta7 in H3 eviction or degradation.
Title: Direct regulation of nucleosome density by the conserved AAA-ATPase Yta7.
the chromatin boundary protein Yta7 as a key regulator that links S-phase kinases with RNAPII function at cell cycle-regulated histone gene promoters.
Title: Restriction of histone gene transcription to S phase by phosphorylation of a chromatin boundary protein.
Data show that the Yta7 bromodomain engages histones for certain cellular functions like barrier chromatin maintenance and particular Spt16/Asf1 cellular pathways of chromatin regulation.
Title: A noncanonical bromodomain in the AAA ATPase protein Yta7 directs chromosomal positioning and barrier chromatin activity.
Deletion of YTA7 affected the enzymatic activity of cis-prenyltransferase (the enzyme that utilizes FPP for dolichol biosynthesis) and the cellular levels of isoprenoid compounds.
Title: The YTA7 gene is involved in the regulation of the isoprenoid pathway in the yeast Saccharomyces cerevisiae.
Epistasis analysis suggests that YTA7 and the HMR-tRNA function independently to restrict the spread of silencing.
Title: Multiple bromodomain genes are involved in restricting the spread of heterochromatic silencing at the Saccharomyces cerevisiae HMR-tRNA boundary.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ATP-dependent chromatin remodeler activity	IDA Inferred from Direct Assay more info	PubMed
enables ATP-dependent chromatin remodeler activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables chromatin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated DNA replication	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA-templated DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleosome assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleosome disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleosome disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of invasive growth in response to glucose limitation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transcription initiation-coupled chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Yta7p

NP_011786.1

Chromatin segregase involved in DNA replication; ATPase activity, stimulated by S phase CDK-dependent phosphorylation, is coupled to nucleosome disassembly, promoting DNA replication; regulates cell-cycle-dependent histone gene expression; contains AAA+-ATPase domains and a non-canonical bromodomain; hexameric; relocalizes to the cytosol in response to hypoxia; human ortholog ATAD2 is a coregulator of oncogenic transcription factors and an oncogene overexpressed in cancers with poor prognosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001139.9 Reference assembly

Range

1027370..1031509

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181399.1 → NP_011786.1 TPA: Yta7p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_011786.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VV47, P40340

UniProtKB/TrEMBL

A0A8H8UL00, B3LHX4, C7GNG4, N1P454

Conserved Domains (3) summary

cd05491
Location:979 → 1098

Bromo_TBP7_like; Bromodomain; TBP7_like subfamily, limited to fungi. TBP7, or TAT-binding protein homolog 7, is a yeast protein of unknown function that contains AAA-superfamily ATP-ase domains and a bromodomain. Bromodomains are found in many chromatin-associated ...

COG0464
Location:430 → 882

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

cd19517
Location:414 → 583

RecA-like_Yta7-like; ATPase domain of Saccharomyces cerevisiae Yta7 and similar ATPase domains