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ARG3 ornithine carbamoyltransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853357, updated on 17-May-2024

Summary

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Gene symbol
ARG3
Gene description
ornithine carbamoyltransferase
Primary source
FungiDB:YJL088W
Locus tag
YJL088W
See related
SGD:S000003624; AllianceGenome:SGD:S000003624
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ornithine carbamoyltransferase activity. Involved in arginine biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in ornithine carbamoyltransferase deficiency. Orthologous to human OTC (ornithine transcarbamylase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (268799..269815)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene protein kinase activating protein DPB11 Neighboring gene Sip4p Neighboring gene tRNA ligase Neighboring gene GTP-Rho binding exocyst subunit EXO70

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The promoter region of the arg3 gene in Saccharomyces cerevisiae: nucleotide sequence and regulation in an arg3-lacZ gene fusion. Crabeel M, et al. EMBO J, 1983. PMID 11894927, Free PMC Article
  2. In situ behavior of the pyrimidine pathway enzymes in Saccharomyces cerevisiae. 4. The channeling of carbamylphosphate to aspartate transcarbamylase and its partition in the pyrimidine and arginine pathways. Penverne B, et al. Arch Biochem Biophys, 1994 Feb 15. PMID 8117117
  3. Cloning arg3, the gene for ornithine carbamoyltransferase from Saccharomyces cerevisiae: expression in Escherichia coli requires secondary mutations; production of plasmid beta-lactamase in yeast. Crabeel M, et al. Proc Natl Acad Sci U S A, 1981 Aug. PMID 7029528, Free PMC Article
  4. Purification and characterization of ornithine transcarbamoylase from Saccharomyces cerevisiae. Eisenstein E, et al. J Biol Chem, 1984 Apr 25. PMID 6370999
  5. Expression of human alpha 1-antitrypsin cDNA in the yeast Saccharomyces cerevisiae. Cabezón T, et al. Proc Natl Acad Sci U S A, 1984 Nov. PMID 6208552, Free PMC Article

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables amino acid binding IEA
Inferred from Electronic Annotation
more info
  
enables carboxyl- or carbamoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ornithine carbamoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ornithine carbamoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ornithine carbamoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arginine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in arginine biosynthetic process via ornithine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in citrulline biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ornithine carbamoyltransferase
NP_012447.1
  • Ornithine carbamoyltransferase; also known as carbamoylphosphate:L-ornithine carbamoyltransferase; catalyzes the biosynthesis of the arginine precursor citrulline

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    268799..269815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181521.1 → NP_012447.1  TPA: ornithine carbamoyltransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012447.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VW96, P05150
    UniProtKB/TrEMBL
    A0A7I9F4T9, A6ZPN7, B3LQ25, C7GR26, C8ZBC5, G2WGT0, N1NZT4
    Conserved Domains (1) summary
    cl39061
    Location:12 → 329
    OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05150.1

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