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CYR1 adenylate cyclase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853452, updated on 17-May-2024

Summary

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Gene symbol
CYR1
Gene description
adenylate cyclase
Primary source
FungiDB:YJL005W
Locus tag
YJL005W
See related
SGD:S000003542; AllianceGenome:SGD:S000003542
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CDC35; FIL1; HSR1; SRA4; TSM0185
Summary
Enables adenylate cyclase activity. Involved in Ras protein signal transduction and adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Located in endoplasmic reticulum membrane; mitochondrion; and plasma membrane. Orthologous to human PHLPP1 (PH domain and leucine rich repeat protein phosphatase 1) and PHLPP2 (PH domain and leucine rich repeat protein phosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (425157..431237)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Ctk2p Neighboring gene tRNA-Leu Neighboring gene Sys1p Neighboring gene Cox16p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Critical function of the Ras-associating domain as a primary Ras-binding site for regulation of Saccharomyces cerevisiae adenylyl cyclase. Kido M, et al. J Biol Chem, 2002 Feb 1. PMID 11723130
  2. A baker's yeast mutant (fil1) with a specific, partially inactivating mutation in adenylate cyclase maintains a high stress resistance during active fermentation and growth. Van Dijck P, et al. J Mol Microbiol Biotechnol, 2000 Oct. PMID 11075928
  3. Characterization of a new set of mutants deficient in fermentation-induced loss of stress resistance for use in frozen dough applications. Van Dijck P, et al. Int J Food Microbiol, 2000 Apr 10. PMID 10791742
  4. Differential structural requirements for interaction of Ras protein with its distinct downstream effectors. Akasaka K, et al. J Biol Chem, 1996 Mar 8. PMID 8621388
  5. Effect of trehalose during stress in a heat-shock resistant mutant of Saccharomyces cerevisiae. Eleutherio EC, et al. Biochem Mol Biol Int, 1995 Aug. PMID 8535293

See all (162) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Snf1 Phosphorylates Adenylate Cyclase and Negatively Regulates Protein Kinase A-dependent Transcription in Saccharomyces cerevisiae
    Title: Snf1 Phosphorylates Adenylate Cyclase and Negatively Regulates Protein Kinase A-dependent Transcription in Saccharomyces cerevisiae.
  2. Adenylate cyclase activity does not influence the Ras2 activation state and is required for the proper interaction between Ras2 and the Ira proteins.
    Title: Evidence for adenylate cyclase as a scaffold protein for Ras2-Ira interaction in Saccharomyces cerevisie.
  3. Protein coding and expression variation of CYR1 enhances the formation of colony biofilms.
    Title: The genetic architecture of biofilm formation in a clinical isolate of Saccharomyces cerevisiae.
  4. Gpa2 relieves the inhibition imposed by the kelch-repeat proteins on Protein Kinase A (PKA), thereby bypassing adenylate cyclase for direct regulation of PKA.
    Title: Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables adenylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables adenylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
adenylate cyclase
NP_012529.3
  • Adenylate cyclase; required for cAMP production and cAMP-dependent protein kinase signaling; scaffold protein for Ras2-Ira interaction; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    425157..431237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181439.3 → NP_012529.3  TPA: adenylate cyclase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012529.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWH0, P08678
    UniProtKB/TrEMBL
    A0A8H4FAL3, N1NZZ2
    Conserved Domains (6) summary
    smart00044
    Location:1613 → 1825
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    PLN00113
    Location:792 → 1273
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:888 → 910
    LRR_RI; leucine-rich repeat [structural motif]
    cd01775
    Location:678 → 776
    RA_PHLPP_like; Ras-associating (RA) domain found in PH domain leucine-rich repeat-containing protein phosphatases, fungal adenylate cyclase, and similar proteins
    pfam08509
    Location:368 → 418
    Ad_cyc_g-alpha; Adenylate cyclase G-alpha binding domain
    pfam00481
    Location:1374 → 1617
    PP2C; Protein phosphatase 2C
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08678.2

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