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AVT1 Avt1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853457, updated on 13-Apr-2024

Summary

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Gene symbol
AVT1
Gene description
Avt1p
Primary source
SGD:S000003761
Locus tag
YJR001W
See related
AllianceGenome:SGD:S000003761
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-glutamine transmembrane transporter activity; L-isoleucine transmembrane transporter activity; and L-tyrosine transmembrane transporter activity. Involved in amino acid transmembrane transport; proline transport; and vacuolar transport. Located in fungal-type vacuole membrane. Orthologous to human SLC32A1 (solute carrier family 32 member 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (436802..438610)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene dolichyl-diphosphooligosaccharide--protein glycotransferase subunit OST1 Neighboring gene proteasome core particle subunit beta 1 Neighboring gene rRNA-processing protein MPP10 Neighboring gene Mrx12p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A PQ-loop protein Ypq2 is involved in the exchange of arginine and histidine across the vacuolar membrane of Saccharomyces cerevisiae. Kawano-Kawada M, et al. Sci Rep, 2019 Oct 21. PMID 31636363, Free PMC Article
  2. Potassium restriction boosts vacuolar acidity and extends lifespan in yeast. Sasikumar AN, et al. Exp Gerontol, 2019 Jun. PMID 30742903, Free PMC Article
  3. Characterization of Avt1p as a vacuolar proton/amino acid antiporter in Saccharomyces cerevisiae. Tone J, et al. Biosci Biotechnol Biochem, 2015. PMID 25747199
  4. Ypq3p-dependent histidine uptake by the vacuolar membrane vesicles of Saccharomyces cerevisiae. Manabe K, et al. Biosci Biotechnol Biochem, 2016 Jun. PMID 26928127
  5. A vacuolar membrane protein Avt7p is involved in transport of amino acid and spore formation in Saccharomyces cerevisiae. Tone J, et al. Biosci Biotechnol Biochem, 2015. PMID 25266154

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Avt1 protein is a proton/amino acid antiporter important for vacuolar compartmentalization of various amino acids.
    Title: Characterization of Avt1p as a vacuolar proton/amino acid antiporter in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-glutamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-isoleucine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-tyrosine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in branched-chain amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proline transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proline transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tyrosine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in fungal-type vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in fungal-type vacuole membrane HDA PubMed 
is_active_in fungal-type vacuole membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fungal-type vacuole membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Avt1p
NP_012534.1
  • Vacuolar transporter; imports large neutral amino acids into vacuole; targeted to vacuole via AP-3 pathway; member of family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    436802..438610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181658.1 → NP_012534.1  TPA: Avt1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012534.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWH5, P47082
    UniProtKB/TrEMBL
    A0A8H4BYS8, A6ZPW7, B3LQ99, C7GUT9, D3UF69, G2WH10, N1NZZ6
    Conserved Domains (1) summary
    pfam01490
    Location:206 → 601
    Aa_trans; Transmembrane amino acid transporter protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P47082.1

Gene LinkOut

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