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ILV3 dihydroxy-acid dehydratase ILV3 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853473, updated on 17-May-2024

Summary

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Gene symbol
ILV3
Gene description
dihydroxy-acid dehydratase ILV3
Primary source
FungiDB:YJR016C
Locus tag
YJR016C
See related
SGD:S000003777; AllianceGenome:SGD:S000003777
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dihydroxy-acid dehydratase activity. Involved in branched-chain amino acid biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (464451..466208, complement)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Tma22p Neighboring gene uncharacterized protein Neighboring gene peptidylprolyl isomerase ESS1 Neighboring gene palmitoyl-CoA hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Aspergillus fumigatus dihydroxyacid dehydratase Ilv3A/IlvC is required for full virulence. Oliver JD, et al. PLoS One, 2012. PMID 23028460, Free PMC Article
  2. Studies on a dehydrase in valine biosynthesis in yeast. WIXOM RL, et al. J Biol Chem, 1960 Jan. PMID 13845531
  3. Cloning of the dihydroxyacid dehydratase-encoding gene (ILV3) from Saccharomyces cerevisiae. Velasco JA, et al. Gene, 1993 Dec 31. PMID 8299945
  4. Cytosolic re-localization and optimization of valine synthesis and catabolism enables inseased isobutanol production with the yeast Saccharomyces cerevisiae. Brat D, et al. Biotechnol Biofuels, 2012 Sep 6. PMID 22954227, Free PMC Article
  5. Specialized function of yeast Isa1 and Isa2 proteins in the maturation of mitochondrial [4Fe-4S] proteins. Mühlenhoff U, et al. J Biol Chem, 2011 Dec 2. PMID 21987576, Free PMC Article

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables dihydroxy-acid dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydroxy-acid dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroxy-acid dehydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydro-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in branched-chain amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in branched-chain amino acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in isoleucine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in valine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dihydroxy-acid dehydratase ILV3
NP_012550.1
  • Dihydroxyacid dehydratase; putative 2Fe-2S protein; catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    464451..466208 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181674.1 → NP_012550.1  TPA: dihydroxy-acid dehydratase ILV3 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012550.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWJ2, P39522
    UniProtKB/TrEMBL
    A0A6A5PWV8, A6ZPY4, B3LQB4, D3UF79, G2WH29, N1P011
    Conserved Domains (1) summary
    TIGR00110
    Location:45 → 584
    ilvD; dihydroxy-acid dehydratase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P39522.2

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