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SOR1 L-iditol 2-dehydrogenase SOR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853624, updated on 27-Jan-2024

Summary

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Gene symbol
SOR1
Gene description
L-iditol 2-dehydrogenase SOR1
Primary source
SGD:S000003920
Locus tag
YJR159W
See related
AllianceGenome:SGD:S000003920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SDH1
Summary
Enables L-iditol 2-dehydrogenase activity. Involved in hexose metabolic process. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
1
Sequence:
Chromosome: X; NC_001142.9 (736044..737117)

Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase Neighboring gene hexose transporter HXT16 Neighboring gene alpha-glucoside permease Neighboring gene Cos5p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Construction of a sorbitol-based vector for expression of heterologous proteins in Saccharomyces cerevisiae. McGonigal T, et al. Appl Environ Microbiol, 1998 Feb. PMID 9464424, Free PMC Article
  2. Cloning and sequence determination of the gene encoding sorbitol dehydrogenase from Saccharomyces cerevisiae. Sarthy AV, et al. Gene, 1994 Mar 11. PMID 8125328
  3. Metabolic engineering considerations for the heterologous expression of xylose-catabolic pathways in Saccharomyces cerevisiae. Jeong D, et al. PLoS One, 2020. PMID 32716960, Free PMC Article
  4. Endogenous xylose pathway in Saccharomyces cerevisiae. Toivari MH, et al. Appl Environ Microbiol, 2004 Jun. PMID 15184173, Free PMC Article
  5. Improving xylitol yield by deletion of endogenous xylitol-assimilating genes: a study of industrial Saccharomyces cerevisiae in fermentation of glucose and xylose. Yang BX, et al. FEMS Yeast Res, 2020 Dec 16. PMID 33201998

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-xylulose reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-iditol 2-dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-iditol 2-dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-iditol 2-dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-iditol 2-dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in hexose metabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in sorbitol catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
L-iditol 2-dehydrogenase SOR1
NP_012693.1
  • Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor2p sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001142.9 Reference assembly

    Range
    736044..737117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181817.1 → NP_012693.1  TPA: L-iditol 2-dehydrogenase SOR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012693.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWX7, P35497
    UniProtKB/TrEMBL
    A6ZX89, B3LHC1, B5VF37, C8Z6M7
    Conserved Domains (1) summary
    cd05285
    Location:8 → 353
    sorbitol_DH; Sorbitol dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35497.1

Gene LinkOut

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