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FAS1 tetrafunctional fatty acid synthase subunit FAS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853653, updated on 13-Apr-2024

Summary

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Gene symbol
FAS1
Gene description
tetrafunctional fatty acid synthase subunit FAS1
Primary source
SGD:S000001665
Locus tag
YKL182W
See related
AllianceGenome:SGD:S000001665
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity; fatty acid synthase activity; and palmitoyltransferase activity. Contributes to fatty acid synthase activity. Involved in long-chain fatty acid biosynthetic process. Located in cytosol and lipid droplet. Part of fatty acid synthase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (100671..106826)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Lot5p Neighboring gene ribose phosphate diphosphokinase subunit PRS1 Neighboring gene ribosomal 60S subunit protein L17A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biphasic modulation of fatty acid synthase by hydrogen peroxide in Saccharomyces cerevisiae. Matias AC, et al. Arch Biochem Biophys, 2011 Nov. PMID 21907179
  2. Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2. Matias AC, et al. Free Radic Biol Med, 2007 Nov 15. PMID 17936191
  3. Genetic analysis of non-complementing fatty acid synthetase mutants in Saccharomyces cerevisiae. Tauro P, et al. Mol Gen Genet, 1974 Mar 14. PMID 4598796
  4. The development and application of a novel chromophoric substrate for investigation of the mechanism of yeast fatty acid synthase. Singh N, et al. Biochem Biophys Res Commun, 1985 Sep 16. PMID 3902014
  5. The pentafunctional FAS1 gene of yeast: its nucleotide sequence and order of the catalytic domains. Schweizer M, et al. Mol Gen Genet, 1986 Jun. PMID 3528750

See all (154) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS).
    Title: Analysis of the co-translational assembly of the fungal fatty acid synthase (FAS).
  2. This study shows that single mutations at domain-domain interfaces can severely perturb substrate shuttling in FAS1.
    Title: Analysis and engineering of substrate shuttling by the acyl carrier protein (ACP) in fatty acid synthases (FASs).
  3. Overexpression of FAS1, FAS2 and Acc1 leads to accumulation of sterols.
    Title: Overexpression of genes of the fatty acid biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae.
  4. Results structurally and functionally characterized the FAS type I PPT as part of the multienzyme protein and as an isolated domain.
    Title: Multimeric options for the auto-activation of the Saccharomyces cerevisiae FAS type I megasynthase.
  5. The crystal structure of the 2.6-MDa Saccharomyces cerevisiae fatty acid synthase (FAS) multienzyme in complex with the antibiotic cerulenin, is presented.
    Title: Inhibition of the fungal fatty acid synthase type I multienzyme complex.
  6. Fatty acid synthase (Fas) plays a key role during the cellular response of Saccharomyces cerevisiae to H2O2.
    Title: Down-regulation of fatty acid synthase increases the resistance of Saccharomyces cerevisiae cells to H2O2.
  7. Sfh2p inhibits fatty acid synthase activity in response to haem depletion
    Title: SFH2 regulates fatty acid synthase activity in the yeast Saccharomyces cerevisiae and is critical to prevent saturated fatty acid accumulation in response to haem and oleic acid depletion.
  8. Study determined crystal structure of fatty acid synthase, which illuminates how this enzyme is initially activated and then carries out multiple steps of synthesis in each of six sterically isolated reaction chambers.
    Title: The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables (3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables [acyl-carrier-protein] S-acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [acyl-carrier-protein] S-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables [acyl-carrier-protein] S-acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables [acyl-carrier-protein] S-malonyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables [acyl-carrier-protein] S-malonyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables [acyl-carrier-protein] S-malonyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables enoyl-[acyl-carrier-protein] reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acyl-[ACP] hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty-acyl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables palmitoyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of fatty acid synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of fatty acid synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of fatty acid synthase complex IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
tetrafunctional fatty acid synthase subunit FAS1
NP_012739.1
  • Beta subunit of fatty acid synthetase; complex catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities; specific target of the broad-spectrum antifungal NPD6433

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    100671..106826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179748.1 → NP_012739.1  TPA: tetrafunctional fatty acid synthase subunit FAS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012739.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VX19, P07149, Q05747
    UniProtKB/TrEMBL
    A0A8H4BZA1, A6ZZE4, C7GJ28, N1P0M8
    Conserved Domains (5) summary
    COG0331
    Location:159 → 536
    FabD; Malonyl CoA-acyl carrier protein transacylase [Lipid transport and metabolism]
    COG4981
    Location:559 → 1350
    COG4981; Enoyl reductase domain of yeast-type FAS1 [Lipid transport and metabolism]
    cd03447
    Location:1536 → 1660
    FAS_MaoC; the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD).
    pfam00698
    Location:1663 → 2037
    Acyl_transf_1; Acyl transferase domain
    pfam17828
    Location:5 → 131
    FAS_N; N-terminal domain in fatty acid synthase subunit beta
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6QL7_G.1
6QL7_H.1
6QL7_I.1
6QL7_J.1
6QL7_K.1
6QL7_L.1
6QL7_g.1
6QL7_h.1
6QL7_i.1
6QL7_j.1
6QL7_k.1
6QL7_l.1
6QL9_G.1
6QL9_J.1
6TA1_C.1
6TA1_E.1
6TA1_G.1
6TA1_H.1
6TA1_J.1
6TA1_L.1
P07149.2

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