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URA1 dihydroorotate dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853664, updated on 13-Apr-2024

Summary

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Gene symbol
URA1
Gene description
dihydroorotate dehydrogenase
Primary source
SGD:S000001699
Locus tag
YKL216W
See related
AllianceGenome:SGD:S000001699
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dihydroorotate dehydrogenase activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process. Located in cytoplasm. Is extrinsic component of membrane. Human ortholog(s) of this gene implicated in postaxial acrofacial dysostosis. Orthologous to human DHODH (dihydroorotate dehydrogenase (quinone)). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (25215..26159)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene threo-3-hydroxy-L-aspartate ammonia-lyase SRY1 Neighboring gene monocarboxylate/H+ symporter Neighboring gene 5-oxoprolinase Neighboring gene Yra2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for transcriptional regulation of dihydroorotic acid dehydrogenase in Saccharomyces cerevisiae. Loison G, et al. Curr Genet, 1981 May. PMID 24190057
  2. Effect of ochre nonsense mutations on yeast URA1 mRNA stability. Pelsy F, et al. Curr Genet, 1984 May. PMID 24177796
  3. Dihydroorotate dehydrogenase from Saccharomyces cerevisiae: spectroscopic investigations with the recombinant enzyme throw light on catalytic properties and metabolism of fumarate analogues. Zameitat E, et al. FEMS Yeast Res, 2007 Sep. PMID 17617217
  4. Horizontal gene transfer promoted evolution of the ability to propagate under anaerobic conditions in yeasts. Gojković Z, et al. Mol Genet Genomics, 2004 May. PMID 15014982
  5. Catalytic properties of dihydroorotate dehydrogenase from Saccharomyces cerevisiae: studies on pH, alternate substrates, and inhibitors. Jordan DB, et al. Arch Biochem Biophys, 2000 Jun 1. PMID 10871048

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables dihydroorotate dehydrogenase (fumarate) activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroorotate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dihydroorotate dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables dihydroorotate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables dihydroorotate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dihydroorotate dehydrogenase
NP_012706.1
  • Dihydroorotate dehydrogenase; catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    25215..26159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179781.1 → NP_012706.1  TPA: dihydroorotate dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012706.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VWY7, P28272, Q2XN75, Q70DC7
    UniProtKB/TrEMBL
    A0A8H4BXQ1, B5VLU9, C7GIZ7, G2WHH8, N1NZQ4
    Conserved Domains (1) summary
    PRK02506
    Location:4 → 314
    PRK02506; dihydroorotate dehydrogenase 1A; Reviewed
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28272.1

Gene LinkOut

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