TGL1 sterol esterase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: TGL1
Gene description: sterol esterase
Primary source: SGD:S000001623
Locus tag: YKL140W
See related: AllianceGenome:SGD:S000001623
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YKL5
Summary: Enables sterol esterase activity. Involved in cellular lipid metabolic process and sterol metabolic process. Located in lipid droplet. Is integral component of membrane. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; cholesterol ester storage disease; and lysosomal and lipase deficiency. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPK (lipase family member K). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (180779..182425)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

this study demonstrates a strong regulation of the two lipid droplet associated steryl ester hydrolases Tgl1p and Yeh1p due to the presence/absence of their host organelle.
Title: The impact of nonpolar lipids on the regulation of the steryl ester hydrolases Tgl1p and Yeh1p in the yeast Saccharomyces cerevisiae.
A deletion of TGL1 resulted in an increase of the cellular steryl ester content
Title: The lipid droplet enzyme Tgl1p hydrolyzes both steryl esters and triglycerides in the yeast, Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables sterol esterase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sterol esterase activity	IDA Inferred from Direct Assay more info	PubMed
enables sterol esterase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in sterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in lipid droplet	IDA Inferred from Direct Assay more info	PubMed
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sterol esterase

NP_012782.1

EC 3.1.1.13

Steryl ester hydrolase; one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

180779..182425

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179706.1 → NP_012782.1 TPA: sterol esterase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012782.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX56, P34163

UniProtKB/TrEMBL

A0A8H4FA75, A6ZZI1, C7GVH6, G2WHP8, N1P2Z2

Conserved Domains (2) summary

pfam00561
Location:106 → 402

Abhydrolase_1; alpha/beta hydrolase fold

pfam04083
Location:66 → 124

Abhydro_lipase; Partial alpha/beta-hydrolase lipase region