RMA1 putative tetrahydrofolate synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: RMA1
Gene description: putative tetrahydrofolate synthase
Primary source: SGD:S000001615
Locus tag: YKL132C
See related: AllianceGenome:SGD:S000001615
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable dihydrofolate synthase activity. Predicted to be involved in folic acid-containing compound biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acid-amino acid ligase activity	IEA Inferred from Electronic Annotation more info
enables acid-amino acid ligase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables dihydrofolate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables tetrahydrofolylpolyglutamate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tetrahydrofolylpolyglutamate synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in dihydrofolate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in folic acid-containing compound biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in folic acid-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolylpolyglutamate biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_012790.1

Putative dihydrofolate synthetase; similar to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; RMA1 has a paralog, FOL3, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain