GFA1 glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: GFA1
Gene description: glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1
Primary source: SGD:S000001587
Locus tag: YKL104C
See related: AllianceGenome:SGD:S000001587
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity. Involved in fungal-type cell wall chitin biosynthetic process. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 12; obesity; and type 2 diabetes mellitus. Orthologous to several human genes including GFPT1 (glutamine--fructose-6-phosphate transaminase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables carbohydrate derivative binding	IEA Inferred from Electronic Annotation more info
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamine-fructose-6-phosphate transaminase (isomerizing) activity	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UDP-N-acetylglucosamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carbohydrate derivative metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fructose 6-phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fungal-type cell wall chitin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fungal-type cell wall chitin biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glutamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein N-linked glycosylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

Preferred Names: glutamine--fructose-6-phosphate transaminase (isomerizing) GFA1

NP_012818.1

Glutamine-fructose-6-phosphate amidotransferase; catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis; GFA1 has a paralogous region, comprising ORFs YMR084W-YMR085W, that arose from the whole genome duplication

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