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ITR2 myo-inositol transporter ITR2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854050, updated on 25-Jan-2024

Summary

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Gene symbol
ITR2
Gene description
myo-inositol transporter ITR2
Primary source
SGD:S000005463
Locus tag
YOL103W
See related
AllianceGenome:SGD:S000005463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HRB612
Summary
Enables myo-inositol transmembrane transporter activity. Involved in myo-inositol transport. Located in plasma membrane. Orthologous to human SLC2A13 (solute carrier family 2 member 13). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (124001..125830)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ndj1p Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tRNA 2'-phosphotransferase Neighboring gene Izh4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Production and reutilization of an extracellular phosphatidylinositol catabolite, glycerophosphoinositol, by Saccharomyces cerevisiae. Patton JL, et al. J Bacteriol, 1995 Jun. PMID 7768846, Free PMC Article
  2. Two major inositol transporters and their role in cryptococcal virulence. Wang Y, et al. Eukaryot Cell, 2011 May. PMID 21398509, Free PMC Article
  3. Role of an expanded inositol transporter repertoire in Cryptococcus neoformans sexual reproduction and virulence. Xue C, et al. mBio, 2010 May 18. PMID 20689743, Free PMC Article
  4. Mutational analysis and localization of the inositol transporters of Saccharomyces cerevisiae. Miyashita M, et al. J Biosci Bioeng, 2003. PMID 16233524
  5. Differential regulation of two myo-inositol transporter genes of Saccharomyces cerevisiae. Nikawa J, et al. Mol Microbiol, 1993 Dec. PMID 7934871

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables myo-inositol transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables myo-inositol:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in myo-inositol import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in myo-inositol transport IEA
Inferred from Electronic Annotation
more info
  
involved_in myo-inositol transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in polyol transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
myo-inositol transporter ITR2
NP_014538.2
  • Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    124001..125830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183357.1 → NP_014538.2  TPA: myo-inositol transporter ITR2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014538.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1W5, P30606
    UniProtKB/TrEMBL
    A0A8H4BVE0, A6ZNA6, B3LIW1, B5VRF1, C7GRV5, C8ZHL1, G2WMD2, N1NZ29
    Conserved Domains (1) summary
    cd17360
    Location:115 → 556
    MFS_HMIT_like; H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30606.2

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