U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

WRS1 tryptophan--tRNA ligase WRS1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854056, updated on 5-May-2024

Summary

Go to the top of the page Help
Gene symbol
WRS1
Gene description
tryptophan--tRNA ligase WRS1
Primary source
SGD:S000005457
Locus tag
YOL097C
See related
AllianceGenome:SGD:S000005457
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HRE342
Summary
Enables tryptophan-tRNA ligase activity. Predicted to be involved in tryptophanyl-tRNA aminoacylation. Located in cytoplasm. Human ortholog(s) of this gene implicated in distal hereditary motor neuronopathy type 9. Orthologous to human WARS1 (tryptophanyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (136527..137825, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene hexaprenyldihydroxybenzoate methyltransferase Neighboring gene ATP-dependent 3'-5' DNA helicase

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design. Zhou M, et al. Nucleic Acids Res, 2010 Jun. PMID 20123733, Free PMC Article
  2. Human tryptophanyl-tRNA synthetase can efficiently complement the Saccharoymces cerevisiae homologue, Wrs1P. Johnson JD, et al. FEMS Microbiol Lett, 2002 Oct 29. PMID 12423761
  3. A view into the origin of life: aminoacyl-tRNA synthetases. Ribas de Pouplana L, et al. Cell Mol Life Sci, 2000 Jun. PMID 10950302
  4. Identification and expression of the Saccharomyces cerevisiae cytoplasmic tryptophanyl-tRNA synthetase gene. John TR, et al. Yeast, 1997 Jan. PMID 9046085
  5. Sequence analysis of a 44 kb DNA fragment of yeast chromosome XV including the Tyl-H3 retrotransposon, the suf1(+) frameshift suppressor gene for tRNA-Gly, the yeast transfer RNA-Thr-1a and a delta element. Vandenbol M, et al. Yeast, 1995 Sep 15. PMID 7502582

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables tryptophan-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tryptophan-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tryptophan-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tryptophanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophanyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
tryptophan--tRNA ligase WRS1
NP_014544.1
  • Cytoplasmic tryptophanyl-tRNA synthetase; aminoacylates tryptophanyl-tRNA; human homolog WARS can complement yeast null mutant

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    136527..137825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183351.1 → NP_014544.1  TPA: tryptophan--tRNA ligase WRS1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014544.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1X1, E9P8Z9, Q12109
    UniProtKB/TrEMBL
    A0A6A5Q723, A6ZNB3, B3LIW6, B5VRF8, C8ZHL8, G2WMD8, N1NX56
    Conserved Domains (1) summary
    cl00015
    Location:25 → 409
    nt_trans; nucleotidyl transferase superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12109.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous