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GSH2 glutathione synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854108, updated on 13-Apr-2024

Summary

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Gene symbol
GSH2
Gene description
glutathione synthase
Primary source
SGD:S000005409
Locus tag
YOL049W
See related
AllianceGenome:SGD:S000005409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables glutathione synthase activity. Involved in glutathione biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; glutathione synthetase deficiency; and hemolytic anemia due to glutathione synthetase deficiency. Orthologous to human GSS (glutathione synthetase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (238619..240094)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Gal11p Neighboring gene Rrt8p Neighboring gene Lds2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cadmium-glutathione solution structures provide new insights into heavy metal detoxification. Delalande O, et al. FEBS J, 2010 Dec. PMID 21078121
  2. Isolation and properties of yeast glutathione synthetase. SNOKE JE. J Biol Chem, 1955 Apr. PMID 14367342
  3. Large conformational changes in the catalytic cycle of glutathione synthase. Gogos A, et al. Structure, 2002 Dec. PMID 12467574
  4. Molecular identification of glutathione synthetase (GSH2) gene from Saccharomyces cerevisiae. Inoue Y, et al. Biochim Biophys Acta, 1998 Feb 11. PMID 9512666
  5. Nickel Oxide (NiO) Nanoparticles Induce Loss of Cell Viability in Yeast Mediated by Oxidative Stress. Sousa CA, et al. Chem Res Toxicol, 2018 Aug 20. PMID 30043610

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GSH1 and GSH2 gene mutations affect glutathione synthetase activity in Saccharomyces cerevisiae.
    Title: Effects of GSH1 and GSH2 Gene Mutation on Glutathione Synthetases Activity of Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables glutathione binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glutathione synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glutathione biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutathione synthase
NP_014593.1
  • Glutathione synthetase; catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    238619..240094
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183303.1 → NP_014593.1  TPA: glutathione synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014593.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W218, Q08220
    UniProtKB/TrEMBL
    A0A8H4BVU3, B3LJ10, C7GK17, C8ZHR5, E9P9L9, N1P2R6
    Conserved Domains (1) summary
    TIGR01986
    Location:11 → 490
    glut_syn_euk; glutathione synthetase, eukaryotic
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08220.1

Gene LinkOut

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