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MSE1 glutamate--tRNA ligase MSE1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854124, updated on 11-Apr-2024

Summary

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Gene symbol
MSE1
Gene description
glutamate--tRNA ligase MSE1
Primary source
SGD:S000005393
Locus tag
YOL033W
See related
AllianceGenome:SGD:S000005393
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable glutamate-tRNA ligase activity. Involved in mitochondrial translation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 12. Orthologous to human EARS2 (glutamyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (263475..265085)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DNA repair ATPase SMC5 Neighboring gene Opi10p Neighboring gene Sil1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial and cytoplasmic isoleucyl-, glutamyl- and arginyl-tRNA synthetases of yeast are encoded by separate genes. Tzagoloff A, et al. Eur J Biochem, 1995 Jun 1. PMID 7607232
  2. CSS-Palm 2.0: an updated software for palmitoylation sites prediction. Ren J, et al. Protein Eng Des Sel, 2008 Nov. PMID 18753194, Free PMC Article
  3. Saccharomyces cerevisiae imports the cytosolic pathway for Gln-tRNA synthesis into the mitochondrion. Rinehart J, et al. Genes Dev, 2005 Mar 1. PMID 15706032, Free PMC Article
  4. Analysis of COPII Vesicles Indicates a Role for the Emp47-Ssp120 Complex in Transport of Cell Surface Glycoproteins. Margulis NG, et al. Traffic, 2016 Mar. PMID 26650540, Free PMC Article
  5. Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins. Hesselberth JR, et al. Genome Biol, 2006. PMID 16606443, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutamate-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables glutamate-tRNA ligase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutamyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glutamyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in glutamyl-tRNA aminoacylation ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in mitochondrial glutamyl-tRNA aminoacylation IC
Inferred by Curator
more info
 PubMed 
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
glutamate--tRNA ligase MSE1
NP_014609.1
  • Mitochondrial glutamyl-tRNA synthetase; predicted to be palmitoylated

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    263475..265085
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183287.1 → NP_014609.1  TPA: glutamate--tRNA ligase MSE1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014609.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W232, P48525, Q08203
    UniProtKB/TrEMBL
    A0A6A5Q775, A6ZNH4, B3LJ24, C7GK03, C8ZHT1, N1NVP7
    Conserved Domains (1) summary
    TIGR00464
    Location:44 → 533
    gltX_bact; glutamyl-tRNA synthetase, bacterial family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P48525.2

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