U.S. flag

An official website of the United States government

SIL1 Sil1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854126, updated on 4-Jan-2025

Summary

Official Symbol
SIL1
Official Full Name
Sil1p
Primary source
SGD:S000005391
Locus tag
YOL031C
See related
AllianceGenome:SGD:S000005391; FungiDB:YOL031C; VEuPathDB:YOL031C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SLS1
Summary
Enables adenyl-nucleotide exchange factor activity. Involved in SRP-dependent cotranslational protein targeting to membrane, translocation. Located in endoplasmic reticulum. Used to study Marinesco-Sjogren syndrome. Human ortholog(s) of this gene implicated in Marinesco-Sjogren syndrome and primary cerebellar degeneration. Orthologous to human SIL1 (SIL1 nucleotide exchange factor). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SIL1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (266264..267529, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene glutamate--tRNA ligase MSE1 Neighboring gene Opi10p Neighboring gene 1,3-beta-glucanosyltransferase Neighboring gene uncharacterized protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
located_in endoplasmic reticulum PubMed 
is_active_in endoplasmic reticulum  
located_in endoplasmic reticulum  
located_in endoplasmic reticulum lumen  

General protein information

Preferred Names
Sil1p
NP_014611.1
  • Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; required for protein translocation into the endoplasmic reticulum (ER); homolog of Yarrowia lipolytica SLS1; GrpE-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    266264..267529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183285.1NP_014611.1  TPA: Sil1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014611.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W234, Q08199, Q6B1H9
    UniProtKB/TrEMBL
    B3LJ26, C7GK01, C8ZHT3, N1NWR5
    Conserved Domains (1) summary
    pfam16782
    Location:123421
    SIL1; Nucleotide exchange factor SIL1
External link. Please review our privacy policy.