CDC21 thymidylate synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: CDC21
Gene description: thymidylate synthase
Primary source: SGD:S000005600
Locus tag: YOR074C
See related: AllianceGenome:SGD:S000005600
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CRT9; TMP1
Summary: Enables thymidylate synthase activity. Involved in dTMP biosynthetic process. Located in nuclear periphery. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and rheumatoid arthritis. Orthologous to human TYMS (thymidylate synthetase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (466675..467589, complement)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

28-bp tandem repeat 3R allele and 6-bp deletion allele (rs34489327) may favor non-response to methotrexate in south Indian Tamils
Title: Effect of thymidylate synthase (TYMS) gene polymorphisms with methotrexate treatment outcome in south Indian Tamil patients with rheumatoid arthritis.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables thymidylate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thymidylate synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables thymidylate synthase activity	IEA Inferred from Electronic Annotation more info
enables thymidylate synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in dTMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in dTMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dTMP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dTTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thymidylate synthase

NP_014717.2

EC 2.1.1.45

Thymidylate synthase; required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S; human homolog TYMSOS can complement yeast cdc21 temperature-sensitive mutant at restrictive temperature

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

466675..467589 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183493.1 → NP_014717.2 TPA: thymidylate synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014717.2

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W2D7, P06785, Q12694

UniProtKB/TrEMBL

A0A6A5Q3R9, B3LJC3, C7GT41, C8ZI35, G2WMV2, N1P314

Conserved Domains (1) summary

PTZ00164
Location:5 → 304

PTZ00164; bifunctional dihydrofolate reductase-thymidylate synthase; Provisional