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THI72 thiamine transporter [ Saccharomyces cerevisiae S288C ]

Gene ID: 854364, updated on 27-Jan-2024

Summary

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Gene symbol
THI72
Gene description
thiamine transporter
Primary source
SGD:S000005718
Locus tag
YOR192C
See related
AllianceGenome:SGD:S000005718
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity. Involved in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport and thiamine transport. Located in cell periphery and fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (698768..700567, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene glucan 1,3-beta-glucosidase Neighboring gene translocase ULS1 Neighboring gene uncharacterized protein Neighboring gene gag-pol fusion protein Neighboring gene gag protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of a thiamin transport gene, THI10, from Saccharomyces cerevisiae. Enjo F, et al. J Biol Chem, 1997 Aug 1. PMID 9235906
  2. Identification of yeast and human 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAr) transporters. Ceschin J, et al. J Biol Chem, 2014 Jun 13. PMID 24778186, Free PMC Article
  3. Characterization of Thi9, a novel thiamine (Vitamin B1) transporter from Schizosaccharomyces pombe. Vogl C, et al. J Biol Chem, 2008 Mar 21. PMID 18201975
  4. Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters. Savocco J, et al. PLoS Biol, 2019 Oct. PMID 31658248, Free PMC Article
  5. Discovering thiamine transporters as targets of chloroquine using a novel functional genomics strategy. Huang Z, et al. PLoS Genet, 2012. PMID 23209439, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters, Thi7, Nrt1, and Thi72.
    Title: Yeast α-arrestin Art2 is the key regulator of ubiquitylation-dependent endocytosis of plasma membrane vitamin B1 transporters.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables nucleobase transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 5-amino-1-ribofuranosylimidazole-4-carboxamide transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nucleobase transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiamine transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
thiamine transporter
NP_014835.3
  • Transporter of thiamine or related compound; contributes to uptake of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (acadesine); shares sequence similarity with Thi7p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    698768..700567 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183611.3 → NP_014835.3  TPA: thiamine transporter [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014835.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2P8, Q08579
    UniProtKB/TrEMBL
    A0A8H4F7I1, A6ZP37, B3LJM2, B5VS76, N1NWR2
    Conserved Domains (1) summary
    cd11482
    Location:27 → 505
    SLC-NCS1sbd_NRT1-like; nucleobase-cation-symport-1 (NCS1) transporter NRT1-like; solute-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08579.1

Gene LinkOut

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