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PUT4 proline permease PUT4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854530, updated on 25-Apr-2024

Summary

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Gene symbol
PUT4
Gene description
proline permease PUT4
Primary source
SGD:S000005875
Locus tag
YOR348C
See related
AllianceGenome:SGD:S000005875
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables L-proline transmembrane transporter activity. Involved in gamma-aminobutyric acid transport and proline transport. Located in plasma membrane. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A2 (solute carrier family 7 member 2); and SLC7A3 (solute carrier family 7 member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (986899..988782, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene deoxycytidyl transferase Neighboring gene pyruvate kinase PYK2 Neighboring gene Cin1p Neighboring gene Mne1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proline transport and stress tolerance of ammonia-insensitive mutants of the PUT4-encoded proline-specific permease in yeast. Poole K, et al. J Gen Appl Microbiol, 2009 Dec. PMID 20118607
  2. Ammonia regulation of amino acid permeases in Saccharomyces cerevisiae. Courchesne WE, et al. Mol Cell Biol, 1983 Apr. PMID 6343842, Free PMC Article
  3. Nitrogen catabolite regulation of proline permease in Saccharomyces cerevisiae. Cloning of the PUT4 gene and study of PUT4 RNA levels in wild-type and mutant strains. Jauniaux JC, et al. Eur J Biochem, 1987 May 4. PMID 3552672
  4. Nucleotide sequence of the Saccharomyces cerevisiae PUT4 proline-permease-encoding gene: similarities between CAN1, HIP1 and PUT4 permeases. Vandenbol M, et al. Gene, 1989 Nov 15. PMID 2687114
  5. Engineering of yeast Put4 permease and its application to lager yeast for efficient proline assimilation. Omura F, et al. Biosci Biotechnol Biochem, 2005 Jun. PMID 15973048

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables L-proline transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables L-proline transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables neutral L-amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in gamma-aminobutyric acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gamma-aminobutyric acid transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neutral amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proline transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proline transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proline permease PUT4
NP_014993.1
  • Proline permease; required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    986899..988782 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183768.1 → NP_014993.1  TPA: proline permease PUT4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014993.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W343, P15380
    UniProtKB/TrEMBL
    A0A8H4BW78, A6ZPH8, B3LK05, B5VSM4, C7GNS0, G2WNK8, N1NXI3
    Conserved Domains (1) summary
    TIGR00913
    Location:107 → 593
    2A0310; amino acid permease (yeast)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15380.2

Gene LinkOut

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