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URA5 orotate phosphoribosyltransferase URA5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854865, updated on 17-May-2024

Summary

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Gene symbol
URA5
Gene description
orotate phosphoribosyltransferase URA5
Primary source
FungiDB:YML106W
Locus tag
YML106W
See related
SGD:S000004574; AllianceGenome:SGD:S000004574
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PYR5
Summary
Enables orotate phosphoribosyltransferase activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process and pyrimidine ribonucleoside biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (56773..57453)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pml39p Neighboring gene RNA-binding signal recognition particle subunit SEC65 Neighboring gene Mdm1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Catalytic site interactions in yeast OMP synthase. Hansen MR, et al. Arch Biochem Biophys, 2014 Jan 15. PMID 24262852
  2. Backbone ¹H, ¹³C, ¹⁵N NMR assignments of yeast OMP synthase in unliganded form and in complex with orotidine 5'-monophosphate. Hansen MR, et al. Biomol NMR Assign, 2014 Apr. PMID 23315339
  3. Ternary complex formation and induced asymmetry in orotate phosphoribosyltransferase. González-Segura L, et al. Biochemistry, 2007 Dec 11. PMID 18020427
  4. 'Irreversible' slow-onset inhibition of orotate phosphoribosyltransferase by an amidrazone phosphate transition-state mimic. Witte JF, et al. Bioorg Med Chem Lett, 2006 Dec 1. PMID 16979338
  5. Half-of-sites binding of orotidine 5'-phosphate and alpha-D-5-phosphorylribose 1-diphosphate to orotate phosphoribosyltransferase from Saccharomyces cerevisiae supports a novel variant of the Theorell-Chance mechanism with alternating site catalysis. McClard RW, et al. Biochemistry, 2006 Apr 25. PMID 16618122

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables orotate phosphoribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables orotate phosphoribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables orotate phosphoribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables orotate phosphoribosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleobase-containing small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyrimidine ribonucleoside biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyrimidine ribonucleoside biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pyrimidine ribonucleoside biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyrimidine-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
orotate phosphoribosyltransferase URA5
NP_013601.1
  • Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    56773..57453
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182468.1 → NP_013601.1  TPA: orotate phosphoribosyltransferase URA5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013601.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0H8, P13298
    UniProtKB/TrEMBL
    A0A6A5PSK7, A6ZLV8, B3LLF3, B5VP25, C7GV88, C8ZE96, G2WJV0, N1NYF4
    Conserved Domains (1) summary
    TIGR00336
    Location:14 → 199
    pyrE; orotate phosphoribosyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13298.2

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