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ALO1 D-arabinono-1,4-lactone oxidase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854888, updated on 5-May-2024

Summary

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Gene symbol
ALO1
Gene description
D-arabinono-1,4-lactone oxidase
Primary source
SGD:S000004551
Locus tag
YML086C
See related
AllianceGenome:SGD:S000004551
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables D-arabinono-1,4-lactone oxidase activity. Involved in cellular response to oxidative stress and dehydro-D-arabinono-1,4-lactone biosynthetic process. Located in mitochondrion. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (95791..97371, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene SCF ubiquitin ligase complex subunit UFO1 Neighboring gene cytochrome-b5 reductase Neighboring gene alpha-tubulin TUB1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bacterial production of D-erythroascorbic acid and L-ascorbic acid through functional expression of Saccharomyces cerevisiae D-arabinono-1,4-lactone oxidase in Escherichia coli. Lee BH, et al. Appl Environ Microbiol, 1999 Oct. PMID 10508108, Free PMC Article
  2. Production of L-ascorbic acid by metabolically engineered Saccharomyces cerevisiae and Zygosaccharomyces bailii. Sauer M, et al. Appl Environ Microbiol, 2004 Oct. PMID 15466554, Free PMC Article
  3. Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae. Burri L, et al. FEBS J, 2006 Apr. PMID 16689936
  4. Mutator genes for suppression of gross chromosomal rearrangements identified by a genome-wide screening in Saccharomyces cerevisiae. Smith S, et al. Proc Natl Acad Sci U S A, 2004 Jun 15. PMID 15184655, Free PMC Article
  5. Protein phosphorylation in mitochondria --a study on fermentative and respiratory growth of Saccharomyces cerevisiae. Ohlmeier S, et al. Electrophoresis, 2010 Sep. PMID 20715123

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-arabinono-1,4-lactone oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-arabinono-1,4-lactone oxidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables D-arabinono-1,4-lactone oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on CH-OH group of donors IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dehydro-D-arabinono-1,4-lactone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial outer membrane HDA PubMed 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
D-arabinono-1,4-lactone oxidase
NP_013624.1
  • D-Arabinono-1,4-lactone oxidase; catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress; null mutant shows improved incorporation efficiency of noncanonical amino acids in place of amber stop codon

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    95791..97371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182445.1 → NP_013624.1  TPA: D-arabinono-1,4-lactone oxidase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013624.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0J7, O42618, P54783
    UniProtKB/TrEMBL
    A0A6A5PQ04, A6ZLX9, B3LLH0, B5VP43, C7GW21, C8ZEB8, G2WJW9, N1P0S5
    Conserved Domains (1) summary
    TIGR01678
    Location:9 → 509
    FAD_lactone_ox; sugar 1,4-lactone oxidases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54783.1

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