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IMD4 IMP dehydrogenase IMD4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854948, updated on 11-Apr-2024

Summary

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Gene symbol
IMD4
Gene description
IMP dehydrogenase IMD4
Primary source
SGD:S000004520
Locus tag
YML056C
See related
AllianceGenome:SGD:S000004520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Predicted to be involved in GTP biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to several human genes including IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
2
Sequence:
Chromosome: XIII; NC_001145.3 (162194..164176, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ribonucleotide reductase inhibiting protein SML1 Neighboring gene calcineurin catalytic subunit A Neighboring gene ncRNA Neighboring gene signal peptidase complex subunit SPC2 Neighboring gene L-lactate dehydrogenase (cytochrome)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid. Köhler GA, et al. J Bacteriol, 1997 Apr. PMID 9079920, Free PMC Article
  2. Proximity to the Promoter and Terminator Regions Regulates the Transcription Enhancement Potential of an Intron. Dwyer K, et al. Front Mol Biosci, 2021. PMID 34291091, Free PMC Article
  3. Functional distinctions between IMP dehydrogenase genes in providing mycophenolate resistance and guanine prototrophy to yeast. Hyle JW, et al. J Biol Chem, 2003 Aug 1. PMID 12746440, Free PMC Article
  4. Participation of yeast inosine 5'-monophosphate dehydrogenase in an in vitro complex with a fragment of the C-rich telomeric strand. Cornuel JF, et al. Biochimie, 2002 Apr. PMID 12106905
  5. IMP dehydrogenase is recruited to the transcription complex through serine 2 phosphorylation of RNA polymerase II. Park JH, et al. Biochem Biophys Res Commun, 2010 Feb 19. PMID 20097157

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables IMP dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables IMP dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables IMP dehydrogenase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables mRNA binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
IMP dehydrogenase IMD4
NP_013656.1
  • Inosine monophosphate dehydrogenase; catalyzes the rate-limiting step in the de novo synthesis of GTP; member of a four-gene family in S. cerevisiae, constitutively expressed; IMD4 has a paralog, IMD3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    162194..164176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182414.1 → NP_013656.1  TPA: IMP dehydrogenase IMD4 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013656.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZB8, P50094, Q2VQW8
    UniProtKB/TrEMBL
    C8ZEF1, G2WK00
    Conserved Domains (1) summary
    PTZ00314
    Location:21 → 519
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50094.1

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