U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GLO1 lactoylglutathione lyase GLO1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855009, updated on 5-May-2024

Summary

Go to the top of the page Help
Gene symbol
GLO1
Gene description
lactoylglutathione lyase GLO1
Primary source
SGD:S000004463
Locus tag
YML004C
See related
AllianceGenome:SGD:S000004463
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables lactoylglutathione lyase activity. Involved in glutathione metabolic process and methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autistic disorder; diabetic retinopathy; end stage renal disease; type 2 diabetes mellitus; and vascular disease. Orthologous to human GLO1 (glyoxalase I). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (261705..262685, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene tRNA-Ser Neighboring gene tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase Neighboring gene uncharacterized protein Neighboring gene Vrl1p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Measuring intracellular enzyme concentrations: Assessing the effect of oxidative stress on the amount of glyoxalase I. Vicente Miranda H, et al. Biochem Mol Biol Educ, 2008 Mar. PMID 21591178
  2. Yeast glyoxalase I is a monomeric enzyme with two active sites. Frickel EM, et al. J Biol Chem, 2001 Jan 19. PMID 11050082
  3. Diffusion-dependent kinetic properties of glyoxalase I and estimates of the steady-state concentrations of glyoxalase-pathway intermediates in glycolyzing erythrocytes. Shih MJ, et al. Eur J Biochem, 1997 Mar 15. PMID 9108256
  4. Reinvestigation of the role of thiol groups of glyoxalase I purified from yeast (Saccharomyces cerevisiae). Caccuri AM, et al. Biochim Biophys Acta, 1993 Sep 3. PMID 8373819
  5. Deuterium isotope effects on the product partitioning of fluoromethylglyoxal by glyoxalase I. Proof of a proton transfer mechanism. Chari RV, et al. J Biol Chem, 1981 Oct 10. PMID 7024272

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables lactoylglutathione lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lactoylglutathione lyase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
lactoylglutathione lyase GLO1
NP_013710.1
  • Monomeric glyoxalase I; catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; required for full activity of O-acetyl homoserine sulfhydrylase, Met17p; expression regulated by methylglyoxal levels and osmotic stress

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    261705..262685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182359.1 → NP_013710.1  TPA: lactoylglutathione lyase GLO1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013710.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZH1, P50107, Q9HFG0, Q9URB5
    UniProtKB/TrEMBL
    A0A8H4BW72, C7GLC1, G2WK49, N1P5A9
    Conserved Domains (1) summary
    cd07233
    Location:23 → 165
    GlxI_Zn; Glyoxalase I that uses Zn(++) as cofactor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50107.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous