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ERG8 phosphomevalonate kinase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855260, updated on 11-Apr-2024

Summary

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Gene symbol
ERG8
Gene description
phosphomevalonate kinase
Primary source
SGD:S000004833
Locus tag
YMR220W
See related
AllianceGenome:SGD:S000004833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphomevalonate kinase activity. Involved in ergosterol biosynthetic process; organic acid phosphorylation; and phospholipid biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (712316..713671)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene transport protein particle complex II subunit TRS130 Neighboring gene Esc1p Neighboring gene Fmp42p Neighboring gene putative serine hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nonorthologous gene displacement of phosphomevalonate kinase. Houten SM, et al. Mol Genet Metab, 2001 Mar. PMID 11243736
  2. Cloning and characterization of ERG8, an essential gene of Saccharomyces cerevisiae that encodes phosphomevalonate kinase. Tsay YH, et al. Mol Cell Biol, 1991 Feb. PMID 1846667, Free PMC Article
  3. Targeted proteomics for metabolic pathway optimization: application to terpene production. Redding-Johanson AM, et al. Metab Eng, 2011 Mar. PMID 21215324
  4. A screening for essential cell growth-related genes involved in arsenite toxicity in Saccharomyces cerevisiae. Takahashi T, et al. J Toxicol Sci, 2011. PMID 22129753
  5. Linking genotype and phenotype of Saccharomyces cerevisiae strains reveals metabolic engineering targets and leads to triterpene hyper-producers. Madsen KM, et al. PLoS One, 2011 Mar 18. PMID 21445244, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphomevalonate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphomevalonate kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphomevalonate kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphomevalonate kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ergosterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ergosterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ergosterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in organic acid phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in vacuole NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
phosphomevalonate kinase
NP_013947.1
  • Phosphomevalonate kinase; an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    712316..713671
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182727.1 → NP_013947.1  TPA: phosphomevalonate kinase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013947.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W045, P24521
    UniProtKB/TrEMBL
    A0A8H4BY17, B3LMA8, C8ZF84
    Conserved Domains (1) summary
    TIGR01219
    Location:6 → 447
    Pmev_kin_ERG8; phosphomevalonate kinase, ERG8-type, eukaryotic branch
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24521.2

Gene LinkOut

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