SCS7 fatty acid alpha-hydroxylase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: SCS7
Gene description: fatty acid alpha-hydroxylase
Primary source: SGD:S000004885
Locus tag: YMR272C
See related: AllianceGenome:SGD:S000004885
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: FAH1
Summary: Enables fatty acid alpha-hydroxylase activity and sphingosine hydroxylase activity. Involved in inositol phosphoceramide metabolic process and very long-chain fatty acid metabolic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 35. Orthologous to human FA2H (fatty acid 2-hydroxylase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (809623..810777, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dihydroceramide fatty acyl 2-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid alpha-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables fatty acid alpha-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid alpha-hydroxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables sphingosine hydroxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in inositol phosphoceramide metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in inositol phosphoceramide metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in very long-chain fatty acid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: fatty acid alpha-hydroxylase

NP_013999.1

EC 1.14.18.6

EC 1.14.18.7

Sphingolipid alpha-hydroxylase; functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

809623..810777 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182779.1 → NP_013999.1 TPA: fatty acid alpha-hydroxylase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013999.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W098, Q03529

UniProtKB/TrEMBL

A0A6A5PTC6, A6ZMY7, B3LMF9, C7GTM8, C8ZFD7, G2WKY0, N1NXQ7

Conserved Domains (2) summary

COG5274
Location:31 → 224

CYB5; Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism]

cl01132
Location:149 → 380

FA_hydroxylase; Fatty acid hydroxylase superfamily