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FKS3 putative 1,3-beta-D-glucan synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855353, updated on 17-May-2024

Summary

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Gene symbol
FKS3
Gene description
putative 1,3-beta-D-glucan synthase
Primary source
FungiDB:YMR306W
Locus tag
YMR306W
See related
SGD:S000004923; AllianceGenome:SGD:S000004923
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable 1,3-beta-D-glucan synthase activity. Involved in ascospore wall assembly. Located in endoplasmic reticulum and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (881159..886516)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene ubiquitin-specific protease UBP15 Neighboring gene putative family 17 glucosidase Neighboring gene 1,3-beta-glucanosyltransferase GAS1 Neighboring gene Pse1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The FKS family genes cause changes in cell wall morphology resulted in regulation of anti-autolytic ability in Saccharomyces cerevisiae. Wang J, et al. Bioresour Technol, 2018 Feb. PMID 29040859
  2. Homologous subunits of 1,3-beta-glucan synthase are important for spore wall assembly in Saccharomyces cerevisiae. Ishihara S, et al. Eukaryot Cell, 2007 Feb. PMID 17158736, Free PMC Article
  3. A microtiter-based fluorescence assay for (1,3)-beta-glucan synthases. Shedletzky E, et al. Anal Biochem, 1997 Jun 15. PMID 9193713
  4. Cell wall synthesis specific cytocidal effect of Hansenula mrakii toxin-1 on Saccharomyces cerevisiae. Takasuka T, et al. Cell Mol Biol Res, 1995. PMID 8777437
  5. Inhibition of yeast (1,3)-beta-glucan synthase by phospholipase A2 and its reaction products. Ko YT, et al. Biochim Biophys Acta, 1994 Jul 13. PMID 8038192

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 1,3-beta-D-glucan synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1,3-beta-D-glucan synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1,3-beta-D-glucan synthase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in (1->3)-beta-D-glucan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in (1->3)-beta-D-glucan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ascospore wall assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall polysaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sporulation resulting in formation of a cellular spore IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of 1,3-beta-D-glucan synthase complex IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
putative 1,3-beta-D-glucan synthase
NP_014036.1
  • Protein involved in spore wall assembly; has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    881159..886516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182817.1 → NP_014036.1  TPA: putative 1,3-beta-D-glucan synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014036.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0D3, Q04952
    UniProtKB/TrEMBL
    A0A8H4BWQ6, B3LMJ4, C7GPV7, C8ZFH5, G2WL15, N1NZ80
    Conserved Domains (2) summary
    pfam02364
    Location:694 → 1542
    Glucan_synthase; 1,3-beta-glucan synthase component
    pfam14288
    Location:182 → 290
    FKS1_dom1; 1,3-beta-glucan synthase subunit FKS1, domain-1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04952.1

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