U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ADH6 NADP-dependent alcohol dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855368, updated on 5-May-2024

Summary

Go to the top of the page Help
Gene symbol
ADH6
Gene description
NADP-dependent alcohol dehydrogenase
Primary source
SGD:S000004937
Locus tag
YMR318C
See related
AllianceGenome:SGD:S000004937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ADHVI
Summary
Enables alcohol dehydrogenase (NADP+) activity; hydroxymethylfurfural reductase (NADH) activity; and hydroxymethylfurfural reductase (NADPH) activity. Involved in alcohol metabolic process and furaldehyde metabolic process. Orthologous to human ZADH2 (zinc binding alcohol dehydrogenase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (911061..912143, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Dia1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fet4p Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Electrochemical probing of in vivo 5-hydroxymethyl furfural reduction in Saccharomyces cerevisiae. Kostesha NV, et al. Anal Chem, 2009 Dec 15. PMID 19925001
  2. Apo and Holo structures of an NADPH-dependent cinnamyl alcohol dehydrogenase from Saccharomyces cerevisiae. Valencia E, et al. J Mol Biol, 2004 Aug 20. PMID 15289102
  3. Properties and functional significance of Saccharomyces cerevisiae ADHVI. Larroy C, et al. Chem Biol Interact, 2003 Feb 1. PMID 12604208
  4. Characterization of the Saccharomyces cerevisiae YMR318C (ADH6) gene product as a broad specificity NADPH-dependent alcohol dehydrogenase: relevance in aldehyde reduction. Larroy C, et al. Biochem J, 2002 Jan 1. PMID 11742541, Free PMC Article
  5. Synthesis of green note aroma compounds by biotransformation of fatty acids using yeast cells coexpressing lipoxygenase and hydroperoxide lyase. Buchhaupt M, et al. Appl Microbiol Biotechnol, 2012 Jan. PMID 21789493

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables 3-methylbutanal reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alcohol dehydrogenase (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables alcohol dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables cinnamyl-alcohol dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxymethylfurfural reductase (NADH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hydroxymethylfurfural reductase (NADPH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in alcohol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in alcohol metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular aldehyde metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in furaldehyde metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
NADP-dependent alcohol dehydrogenase
NP_014051.3
  • NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    911061..912143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182831.3 → NP_014051.3  TPA: NADP-dependent alcohol dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014051.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0E6, Q04894
    UniProtKB/TrEMBL
    A0A7I9FXN4, A6ZN36, B3LMK7, B5VQ85, C7GPU5, C8ZFJ1, G2WL30, N1NYX0
    Conserved Domains (1) summary
    cd05283
    Location:8 → 352
    CAD1; Cinnamyl alcohol dehydrogenases (CAD)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04894.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous