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ALP1 arginine permease ALP1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855451, updated on 13-Apr-2024

Summary

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Gene symbol
ALP1
Gene description
arginine permease ALP1
Primary source
SGD:S000005214
Locus tag
YNL270C
See related
AllianceGenome:SGD:S000005214
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
APL1
Summary
Enables basic amino acid transmembrane transporter activity. Involved in basic amino acid transport. Located in endoplasmic reticulum. Orthologous to several human genes including SLC7A1 (solute carrier family 7 member 1); SLC7A2 (solute carrier family 7 member 2); and SLC7A3 (solute carrier family 7 member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (135940..137661, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene guanine nucleotide exchange factor SEC2 Neighboring gene formin BNI1 Neighboring gene Bsc4p Neighboring gene lysine permease

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The sequence of a 24,152 bp segment from the left arm of chromosome XIV from Saccharomyces cerevisiae between the BNI1 and the POL2 genes. Sen-Gupta M, et al. Yeast, 1996 Apr. PMID 8740425
  2. APL1, a yeast gene encoding a putative permease for basic amino acids. Sychrova H, et al. Yeast, 1994 May. PMID 7941748
  3. Transport in isolated yeast vacuoles: characterization of arginine permease. Boller T, et al. Methods Enzymol, 1989. PMID 2698990
  4. Effects of three permeases on arginine utilization in Saccharomyces cerevisiae. Zhang P, et al. Sci Rep, 2016 Feb 11. PMID 26865023, Free PMC Article
  5. Metabolic engineering of arginine permeases to reduce the formation of urea in Saccharomyces cerevisiae. Zhang P, et al. World J Microbiol Biotechnol, 2018 Mar 13. PMID 29536194

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables basic amino acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in amino acid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in basic amino acid transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in basic amino acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nitrogen compound transport IEA
Inferred from Electronic Annotation
more info
  
involved_in organic substance transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
arginine permease ALP1
NP_014129.1
  • Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression; ALP1 has a paralog, CAN1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    135940..137661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183108.1 → NP_014129.1  TPA: arginine permease ALP1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014129.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0S4, P38971
    UniProtKB/TrEMBL
    A0A8H4BWU0, B3LPA9, C7GP93, C8ZFW9
    Conserved Domains (1) summary
    TIGR00913
    Location:67 → 545
    2A0310; amino acid permease (yeast)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38971.2

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