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KEX2 kexin KEX2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855483, updated on 4-Jan-2025

Summary

Official Symbol
KEX2
Official Full Name
kexin KEX2
Primary source
SGD:S000005182
Locus tag
YNL238W
See related
AllianceGenome:SGD:S000005182; FungiDB:YNL238W; VEuPathDB:YNL238W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
QDS1; SRB1; VMA45
Summary
Enables serine-type endopeptidase activity. Involved in peptide pheromone maturation. Located in trans-Golgi network. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; obesity; and proprotein convertase 1/3 deficiency. Orthologous to several human genes including PCSK7 (proprotein convertase subtilisin/kexin type 7). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See KEX2 in Genome Data Viewer
Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (202428..204872)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene iron-sulfur cluster assembly protein NAR1 Neighboring gene bleomycin hydrolase Neighboring gene Ytp1p Neighboring gene Sin4p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding  
enables serine-type endopeptidase activity  
enables serine-type endopeptidase activity PubMed 
enables serine-type endopeptidase activity  
enables serine-type peptidase activity  
Process Evidence Code Pubs
involved_in peptide pheromone maturation PubMed 
involved_in protein processing  
involved_in proteolysis  
Component Evidence Code Pubs
located_in Golgi apparatus  
is_active_in Golgi membrane  
located_in cytoplasm  
located_in endomembrane system  
located_in fungal-type vacuole PubMed 
located_in intracellular membrane-bounded organelle  
located_in membrane  
is_active_in trans-Golgi network  
located_in trans-Golgi network PubMed 

General protein information

Preferred Names
kexin KEX2
NP_014161.1
  • Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    202428..204872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183076.1NP_014161.1  TPA: kexin KEX2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014161.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0V5, P13134
    UniProtKB/TrEMBL
    B3LP77, C8ZFZ8
    Conserved Domains (2) summary
    cd04059
    Location:133419
    Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases
    COG4935
    Location:463653
    COG4935; Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]
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