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CYB5 Cyb5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855612, updated on 13-Apr-2024

Summary

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Gene symbol
CYB5
Gene description
Cyb5p
Primary source
SGD:S000005055
Locus tag
YNL111C
See related
AllianceGenome:SGD:S000005055
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables electron transfer activity. Involved in sterol biosynthetic process. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in methemoglobinemia and methemoglobinemia and ambiguous genitalia. Orthologous to human CYB5A (cytochrome b5 type A) and CYB5B (cytochrome b5 type B). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (416940..417302, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase core subunit RPC19 Neighboring gene DEAD-box ATP-dependent RNA helicase DBP2 Neighboring gene rRNA-binding ribosome biosynthesis protein NOP15 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Improvement of polyunsaturated fatty acids synthesis by the coexpression of CYB5 with desaturase genes in Saccharomyces cerevisiae. Yazawa H, et al. Appl Microbiol Biotechnol, 2010 Aug. PMID 20512324
  2. Purification and characterization of intact cytochrome b5 from yeast microsomes. Yoshida Y, et al. Arch Biochem Biophys, 1983 Feb 1. PMID 6337556
  3. Biodiversity of the P450 catalytic cycle: yeast cytochrome b5/NADH cytochrome b5 reductase complex efficiently drives the entire sterol 14-demethylation (CYP51) reaction. Lamb DC, et al. FEBS Lett, 1999 Dec 3. PMID 10622712
  4. Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain. Truan G, et al. Gene, 1994 May 3. PMID 8181746
  5. The DNA sequence of cosmid 14-13b from chromosome XIV of Saccharomyces cerevisiae reveals an unusually high number of overlapping open reading frames. De Antoni A, et al. Yeast, 1997 Mar 15. PMID 9090055

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in sterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cyb5p
NP_014288.3
  • Cytochrome b5; involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    416940..417302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182949.3 → NP_014288.3  TPA: Cyb5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014288.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W170, P40312
    UniProtKB/TrEMBL
    A0A6A5Q7B8, A6ZRX1, B3LNW8, C7GKD3, C8ZGB9, G2WLZ5, N1NXW5
    Conserved Domains (1) summary
    COG5274
    Location:1 → 119
    CYB5; Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40312.2

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