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PET8 Pet8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855729, updated on 5-May-2024

Summary

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Gene symbol
PET8
Gene description
Pet8p
Primary source
SGD:S000004948
Locus tag
YNL003C
See related
AllianceGenome:SGD:S000004948
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
SAM5
Summary
Enables S-adenosyl-L-methionine transmembrane transporter activity. Involved in S-adenosyl-L-methionine transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 28. Orthologous to human SLC25A26 (solute carrier family 25 member 26). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XIV
Exon count:
1
Sequence:
Chromosome: XIV; NC_001146.8 (624975..625829, complement)

Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL2 Neighboring gene mRNA-binding protein Neighboring gene Rlp7p Neighboring gene ribosome dissociation factor DOM34

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and functional reconstitution of yeast mitochondrial carrier for S-adenosylmethionine. Marobbio CM, et al. EMBO J, 2003 Nov 17. PMID 14609944, Free PMC Article
  2. Organization of the centromeric region of chromosome XIV in Saccharomyces cerevisiae. Lalo D, et al. Yeast, 1994 Apr. PMID 7941739
  3. SLC25 Family Member Genetic Interactions Identify a Role for HEM25 in Yeast Electron Transport Chain Stability. Dufay JN, et al. G3 (Bethesda), 2017 Jun 7. PMID 28404662, Free PMC Article
  4. Characterization of mitochondrial carrier proteins of malaria parasite Plasmodium falciparum based on in vitro translation and reconstitution. Nozawa A, et al. Parasitol Int, 2020 Dec. PMID 32574727
  5. Phylogenetic classification of the mitochondrial carrier family of Saccharomyces cerevisiae. el Moualij B, et al. Yeast, 1997 May. PMID 9178508

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables S-adenosyl-L-methionine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-adenosyl-L-methionine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables S-adenosyl-L-methionine transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables S-adenosyl-L-methionine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in S-adenosyl-L-methionine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in S-adenosyl-L-methionine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in S-adenosyl-L-methionine transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in S-adenosyl-L-methionine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pet8p
NP_014395.3
  • S-adenosylmethionine transporter of the mitochondrial inner membrane; member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001146.8 Reference assembly

    Range
    624975..625829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182842.3 → NP_014395.3  TPA: Pet8p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014395.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1H4, P38921
    UniProtKB/TrEMBL
    A0A8H4BVW6, A6ZS73, B3LPP1, C7GJE2, C8ZFM3, G2WL56, N1NY42
    Conserved Domains (1) summary
    PTZ00168
    Location:5 → 263
    PTZ00168; mitochondrial carrier protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38921.1

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