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ODC1 mitochondrial 2-oxodicarboxylate carrier [ Saccharomyces cerevisiae S288C ]

Gene ID: 855969, updated on 11-Apr-2024

Summary

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Gene symbol
ODC1
Gene description
mitochondrial 2-oxodicarboxylate carrier
Primary source
SGD:S000006055
Locus tag
YPL134C
See related
AllianceGenome:SGD:S000006055
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables dicarboxylic acid transmembrane transporter activity. Involved in mitochondrial transport. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome. Orthologous to human SLC25A21 (solute carrier family 25 member 21). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (298571..299503, complement)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene protein phosphatase regulator GIP3 Neighboring gene iron-binding protein ISU1 Neighboring gene gluconeogenesis transcription factor RDS2 Neighboring gene Cox11p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deregulating mitochondrial metabolite and ion transport has beneficial effects in yeast and human cellular models for NARP syndrome. Su X, et al. Hum Mol Genet, 2019 Nov 15. PMID 31276579
  2. Overexpression of mitochondrial oxodicarboxylate carrier (ODC1) preserves oxidative phosphorylation in a yeast model of Barth syndrome. de Taffin de Tilques M, et al. Dis Model Mech, 2017 Apr 1. PMID 28188263, Free PMC Article
  3. Yeast mitochondrial oxodicarboxylate transporters are important for growth on oleic acid. Tibbetts AS, et al. Arch Biochem Biophys, 2002 Oct 1. PMID 12234495
  4. Identification in Saccharomyces cerevisiae of two isoforms of a novel mitochondrial transporter for 2-oxoadipate and 2-oxoglutarate. Palmieri L, et al. J Biol Chem, 2001 Jan 19. PMID 11013234
  5. Three mitochondrial transporters of Saccharomyces cerevisiae are essential for ammonium fixation and lysine biosynthesis in synthetic minimal medium. Scarcia P, et al. Mol Genet Metab, 2017 Nov. PMID 28784321

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the suppression of the respiratory-growth-deficient fmc1 by the overexpressed Odc1p was not due to a restored stable ATP synthase.
    Title: Increasing mitochondrial substrate-level phosphorylation can rescue respiratory growth of an ATP synthase-deficient yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP:ADP antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables L-aspartate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dicarboxylic acid transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-aspartate transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in malate-aspartate shuttle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial ADP transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial ATP transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitochondrial 2-oxodicarboxylate carrier
NP_015191.1
  • Mitochondrial inner membrane transporter; 2-oxodicarboxylate transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation; ODC1 has a paralog, ODC2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    298571..299503 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183948.1 → NP_015191.1  TPA: mitochondrial 2-oxodicarboxylate carrier [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015191.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3N3, Q03028
    UniProtKB/TrEMBL
    A0A6A5Q573, A6ZWB8, B3LKU1, B5VT31, C7GJ87, C8ZIP6, G2WP47, N1NX22
    Conserved Domains (2) summary
    PTZ00169
    Location:11 → 302
    PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional
    pfam00153
    Location:8 → 113
    Mito_carr; Mitochondrial carrier protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03028.1

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