U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PMA2 H(+)-exporting P2-type ATPase PMA2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856071, updated on 5-May-2024

Summary

Go to the top of the page Help
Gene symbol
PMA2
Gene description
H(+)-exporting P2-type ATPase PMA2
Primary source
SGD:S000005957
Locus tag
YPL036W
See related
AllianceGenome:SGD:S000005957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables P-type proton-exporting transporter activity. Involved in proton transmembrane transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in Hailey-Hailey disease. Orthologous to human ATP2C1 (ATPase secretory pathway Ca2+ transporting 1) and ATP2C2 (ATPase secretory pathway Ca2+ transporting 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (482843..485686)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Met31p Neighboring gene Egd1p Neighboring gene uncharacterized protein Neighboring gene Srl4p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulation of the expression of the H(+)-ATPase genes PMA1 and PMA2 during growth and effects of octanoic acid in Saccharomyces cerevisiae. Viegas CA, et al. Biochim Biophys Acta, 1994 Jan 18. PMID 8286419
  2. In-frame recombination between the yeast H(+)-ATPase isogenes PMA1 and PMA2: insights into the mechanism of recombination initiated by a double-strand break. Supply P, et al. Mol Cell Biol, 1995 Oct. PMID 7565689, Free PMC Article
  3. Adaptative responses in yeast to the herbicide 2-methyl-4-chlorophenoxyacetic acid at the level of intracellular pH homeostasis. Guadalupe Cabral M, et al. J Appl Microbiol, 2004. PMID 14962141
  4. Transcription patterns of PMA1 and PMA2 genes and activity of plasma membrane H+-ATPase in Saccharomyces cerevisiae during diauxic growth and stationary phase. Fernandes AR, et al. Yeast, 2003 Feb. PMID 12557274
  5. The activity of plasma membrane H(+)-ATPase is strongly stimulated during Saccharomyces cerevisiae adaptation to growth under high copper stress, accompanying intracellular acidification. Fernandes AR, et al. Yeast, 2001 Apr. PMID 11284007

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type ion transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables P-type proton-exporting transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables P-type proton-exporting transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables P-type proton-exporting transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables inorganic cation transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in inorganic cation transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton export across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in plasma membrane HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
H(+)-exporting P2-type ATPase PMA2
NP_015289.1
  • Plasma membrane H+-ATPase; isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    482843..485686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183850.1 → NP_015289.1  TPA: H(+)-exporting P2-type ATPase PMA2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015289.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W3X8, P19657
    UniProtKB/TrEMBL
    A0A8H4BW74, A6ZWL2, C7GU18, N1NVZ2
    Conserved Domains (1) summary
    cd02076
    Location:116 → 903
    P-type_ATPase_H; plant and fungal plasma membrane H(+)-ATPases, and related bacterial and archaeal putative H(+)-ATPases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19657.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous