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ATP20 F1F0 ATP synthase subunit g [ Saccharomyces cerevisiae S288C ]

Gene ID: 856131, updated on 11-Apr-2024

Summary

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Gene symbol
ATP20
Gene description
F1F0 ATP synthase subunit g
Primary source
SGD:S000006224
Locus tag
YPR020W
See related
AllianceGenome:SGD:S000006224
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Contributes to proton-transporting ATP synthase activity, rotational mechanism. Involved in ATP synthesis coupled proton transport; cristae formation; and protein-containing complex assembly. Located in mitochondrion. Part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Orthologous to human ATP5MG (ATP synthase membrane subunit g) and ATP5MGL (ATP synthase membrane subunit g like). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (599870..600217)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rlf2p Neighboring gene MCM DNA helicase complex subunit MCM4 Neighboring gene citrin Neighboring gene Sdd4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kinetic coupling of the respiratory chain with ATP synthase, but not proton gradients, drives ATP production in cristae membranes. Toth A, et al. Proc Natl Acad Sci U S A, 2020 Feb 4. PMID 31964824, Free PMC Article
  2. Identification of subunit g of yeast mitochondrial F1F0-ATP synthase, a protein required for maximal activity of cytochrome c oxidase. Boyle GM, et al. Eur J Biochem, 1999 Jun. PMID 10336613
  3. Arg-8 of yeast subunit e contributes to the stability of F-ATP synthase dimers and to the generation of the full-conductance mitochondrial megachannel. Guo L, et al. J Biol Chem, 2019 Jul 12. PMID 31160339, Free PMC Article
  4. Mitochondrial F1Fo-ATP synthase: the small subunits e and g associate with monomeric complexes to trigger dimerization. Wagner K, et al. J Mol Biol, 2009 Oct 2. PMID 19635484
  5. The intermembrane space loop of subunit b (4) is a major determinant of the stability of yeast oligomeric ATP synthases. Weimann T, et al. Biochemistry, 2008 Mar 18. PMID 18293929

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that Su k (Atp19) and Su i (Atp18) are involved in the assembly of Su e (Atp21) and Su g (Atp20) F(1)F(o)-ATP synthase dimers and oligomers.
    Title: Stepwise assembly of dimeric F(1)F(o)-ATP synthase in mitochondria involves the small F(o)-subunits k and i.
  2. Association of Su e and Su g with monomeric F(1)F(o)-ATP synthase represents an initial step of oligomer formation.
    Title: Mitochondrial F1Fo-ATP synthase: the small subunits e and g associate with monomeric complexes to trigger dimerization.
  3. Results propose a model in which the antagonism between Fcj1 and Su e/g locally modulates the F(1)F(O) oligomeric state, thereby controlling membrane curvature of cristae to generate crista junctions and cristae tips.
    Title: Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g.
  4. the GXXXG motif may not be the sole basis for a Su g-Su e interaction within F1F0-ATPase
    Title: The yeast F(1)F(0)-ATP synthase: analysis of the molecular organization of subunit g and the importance of a conserved GXXXG motif.
  5. the conserved GXXXG motif of the membrane-spanning segment of subunit g has a role in the supramolecular species of yeast ATP synthase
    Title: The modification of the conserved GXXXG motif of the membrane-spanning segment of subunit g destabilizes the supramolecular species of yeast ATP synthase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cristae formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven ATP synthesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proton motive force-driven ATP synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton motive force-driven ATP synthesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
F1F0 ATP synthase subunit g
NP_015345.1
  • Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex, which in turn determines oligomerization of the complex and the shape of inner membrane cristae

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    599870..600217
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184117.1 → NP_015345.1  TPA: F1F0 ATP synthase subunit g [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015345.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W430, Q12233
    UniProtKB/TrEMBL
    A0A6A5Q5A2, A6ZWR3, B3LL81, C7GQB8, C8ZJ45, G2WPJ8, N1NVJ4
    Conserved Domains (1) summary
    pfam04718
    Location:14 → 112
    ATP-synt_G; Mitochondrial ATP synthase g subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12233.1

Gene LinkOut

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