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MSF1 phenylalanine--tRNA ligase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856160, updated on 13-Apr-2024

Summary

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Gene symbol
MSF1
Gene description
phenylalanine--tRNA ligase
Primary source
SGD:S000006251
Locus tag
YPR047W
See related
AllianceGenome:SGD:S000006251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phenylalanine-tRNA ligase activity. Involved in mitochondrial phenylalanyl-tRNA aminoacylation. Located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 14 and hereditary spastic paraplegia 77. Orthologous to human FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (657529..658938)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Thp3p Neighboring gene Mcm16p Neighboring gene NAPDH-dependent diflavin reductase Neighboring gene autophagy protein ATG11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Reversible inactivation of yeast mitochondrial phenylalanyl-tRNA synthetase under oxidative stress. Chakraborty S, et al. Biochim Biophys Acta Gen Subj, 2018 Aug. PMID 29723545
  2. Isolation and characterization of the yeast gene coding for the alpha subunit of mitochondrial phenylalanyl-tRNA synthetase. Koerner TJ, et al. J Biol Chem, 1987 Mar 15. PMID 3029120
  3. Evolution of aminoacyl-tRNA synthetase quaternary structure and activity: Saccharomyces cerevisiae mitochondrial phenylalanyl-tRNA synthetase. Sanni A, et al. Proc Natl Acad Sci U S A, 1991 Oct 1. PMID 1924298, Free PMC Article
  4. Loss of editing activity during the evolution of mitochondrial phenylalanyl-tRNA synthetase. Roy H, et al. J Biol Chem, 2005 Nov 18. PMID 16162501
  5. Structure of the metal.nucleotide complex in the yeast phenylalanyl transfer ribonucleic acid synthetase reaction as determined with diastereomeric phosphorothioate analogs of ATP. Connolly BA, et al. J Biol Chem, 1980 Dec 10. PMID 7002919

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity, acting on a tRNA IEA
Inferred from Electronic Annotation
more info
  
enables phenylalanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phenylalanine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phenylalanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables phenylalanine-tRNA ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial phenylalanyl-tRNA aminoacylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylalanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
phenylalanine--tRNA ligase
NP_015372.2
  • Mitochondrial phenylalanyl-tRNA synthetase; active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    657529..658938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184144.1 → NP_015372.2  TPA: phenylalanine--tRNA ligase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015372.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W455, P08425, Q12410
    UniProtKB/TrEMBL
    A0A8H4BV02, A6ZWT8, B3LLA5, C7GY36, C8ZJ72, G2WPM3
    Conserved Domains (1) summary
    TIGR00469
    Location:18 → 468
    pheS_mito; phenylalanyl-tRNA synthetase, mitochondrial
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08425.3

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