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QCR2 ubiquinol--cytochrome-c reductase subunit 2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856321, updated on 5-May-2024

Summary

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Gene symbol
QCR2
Gene description
ubiquinol--cytochrome-c reductase subunit 2
Primary source
SGD:S000006395
Locus tag
YPR191W
See related
AllianceGenome:SGD:S000006395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
COR2; UCR2
Summary
Contributes to ubiquinol-cytochrome-c reductase activity. Involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrial crista. Part of mitochondrial respiratory chain complex III. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: XVI
Exon count:
1
Sequence:
Chromosome: XVI; NC_001148.4 (919381..920487)

Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene SKI complex subunit tetratricopeptide repeat protein SKI3 Neighboring gene DNA-directed RNA polymerase III subunit C82 Neighboring gene Aqy1p Neighboring gene histone acetyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Subunit II of yeast QH2:cytochrome-c oxidoreductase. Nucleotide sequence of the gene and features of the protein. Oudshoorn P, et al. Eur J Biochem, 1987 Feb 16. PMID 3028797
  2. Expression of the gene encoding subunit II of yeast QH2: cytochrome c oxidoreductase is regulated by multiple factors. Dorsman JC, et al. Curr Genet, 1990 Jun. PMID 2167771
  3. A point mutation in the mitochondrial cytochrome b gene obviates the requirement for the nuclear encoded core protein 2 subunit in the cytochrome bc1 complex in Saccharomyces cerevisiae. di Rago JP, et al. J Biol Chem, 1997 Feb 21. PMID 9030521
  4. A Genome-Wide Screen in Saccharomyces cerevisiae Reveals a Critical Role for Oxidative Phosphorylation in Cellular Tolerance to Lithium Hexafluorophosphate. Jin X, et al. Cells, 2021 Apr 13. PMID 33924665, Free PMC Article
  5. Mechanism of imidazolium ionic liquids toxicity in Saccharomyces cerevisiae and rational engineering of a tolerant, xylose-fermenting strain. Dickinson Q, et al. Microb Cell Fact, 2016 Jan 20. PMID 26790958, Free PMC Article

See all (126) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial crista IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial respiratory chain complex III IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in respirasome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquinol--cytochrome-c reductase subunit 2
NP_015517.1
  • Subunit 2 of ubiquinol cytochrome-c reductase (Complex III); Complex III is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001148.4 Reference assembly

    Range
    919381..920487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184288.1 → NP_015517.1  TPA: ubiquinol--cytochrome-c reductase subunit 2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_015517.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W4J1, P07257
    UniProtKB/TrEMBL
    A0A6A5Q625, A6ZX65, G2WQ02, N1NXW6
    Conserved Domains (2) summary
    COG0612
    Location:1 → 362
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    pfam00675
    Location:17 → 163
    Peptidase_M16; Insulinase (Peptidase family M16)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P07257.1

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