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DUR3 Dur3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 856370, updated on 17-May-2024

Summary

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Gene symbol
DUR3
Gene description
Dur3p
Primary source
FungiDB:YHL016C
Locus tag
YHL016C
See related
SGD:S000001008; AllianceGenome:SGD:S000001008
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables putrescine transmembrane transporter activity; spermidine transmembrane transporter activity; and urea transmembrane transporter activity. Involved in putrescine transport; spermidine transport; and urea transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism and thyroid dyshormonogenesis 1. Orthologous to human SLC5A12 (solute carrier family 5 member 12); SLC5A5 (solute carrier family 5 member 5); and SLC5A8 (solute carrier family 5 member 8). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DUR3 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (72037..74244, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene 4a-hydroxytetrahydrobiopterin dehydratase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ribosomal 40S subunit protein S20

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutant Potential Ubiquitination Sites in Dur3p Enhance the Urea and Ethyl Carbamate Reduction in a Model Rice Wine System. Zhang P, et al. J Agric Food Chem, 2017 Mar 1. PMID 28185458
  2. Regulation of the urea active transporter gene (DUR3) in Saccharomyces cerevisiae. ElBerry HM, et al. J Bacteriol, 1993 Aug. PMID 8335627, Free PMC Article
  3. Single-cell copy number variant detection reveals the dynamics and diversity of adaptation. Lauer S, et al. PLoS Biol, 2018 Dec. PMID 30562346, Free PMC Article
  4. Polyamine uptake by DUR3 and SAM3 in Saccharomyces cerevisiae. Uemura T, et al. J Biol Chem, 2007 Mar 9. PMID 17218313
  5. A second nitrogen permease regulator in Saccharomyces cerevisiae. Rousselet G, et al. FEBS Lett, 1995 Feb 13. PMID 7867803

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mutation of Dur3p ubiquitination sites could significantly affect urea utilization and formation.
    Title: Mutant Potential Ubiquitination Sites in Dur3p Enhance the Urea and Ethyl Carbamate Reduction in a Model Rice Wine System.
  2. DUR3 and SAM3 are major polyamine uptake proteins in yeast.
    Title: Polyamine uptake by DUR3 and SAM3 in Saccharomyces cerevisiae.
  3. These results suggest that, in addition to the efflux boron transporter BOR1, DUR3 and FPS1 play important roles in regulating the cellular boron concentration.
    Title: Roles of BOR1, DUR3, and FPS1 in boron transport and tolerance in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables putrescine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables putrescine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables putrescine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables spermidine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables spermidine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables spermidine transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables urea transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables urea transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables urea transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in putrescine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in putrescine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in putrescine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermidine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in spermidine transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermidine transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermidine transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in urea transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in urea transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in urea transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Dur3p
NP_011847.1
  • Plasma membrane transporter for both urea and polyamines; expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    72037..74244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179096.1 → NP_011847.1  TPA: Dur3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011847.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DKP5, P33413
    UniProtKB/TrEMBL
    A0A8H4BZJ8, B3LSA2, C7GIS0, G2WF50, N1P9J3
    Conserved Domains (1) summary
    cd11476
    Location:14 → 517
    SLC5sbd_DUR3; Na(+)/urea-polyamine cotransporter DUR3, and related proteins; solute-binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P33413.2

Gene LinkOut

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