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MSR1 arginine--tRNA ligase MSR1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856491, updated on 13-Apr-2024

Summary

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Gene symbol
MSR1
Gene description
arginine--tRNA ligase MSR1
Primary source
SGD:S000001133
Locus tag
YHR091C
See related
AllianceGenome:SGD:S000001133
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable arginine-tRNA ligase activity. Involved in mitochondrial translation. Located in mitochondrion. Used to study pontocerebellar hypoplasia type 6. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 6. Orthologous to human RARS2 (arginyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (284839..286770, complement)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene H/ACA snoRNP pseudouridylase subunit GAR1 Neighboring gene histone acetyltransferase YNG2 Neighboring gene hexose transporter HXT4 Neighboring gene Aht1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pontocerebellar hypoplasia type 6 caused by mutations in RARS2: definition of the clinical spectrum and molecular findings in five patients. Cassandrini D, et al. J Inherit Metab Dis, 2013 Jan. PMID 22569581
  2. Mitochondrial and cytoplasmic isoleucyl-, glutamyl- and arginyl-tRNA synthetases of yeast are encoded by separate genes. Tzagoloff A, et al. Eur J Biochem, 1995 Jun 1. PMID 7607232
  3. Genome-Wide Dynamic Evaluation of the UV-Induced DNA Damage Response. Silva E, et al. G3 (Bethesda), 2020 Sep 2. PMID 32732306, Free PMC Article
  4. Arginine aminoacylation identity is context-dependent and ensured by alternate recognition sets in the anticodon loop of accepting tRNA transcripts. Sissler M, et al. EMBO J, 1996 Sep 16. PMID 8890180, Free PMC Article
  5. Functional genomics analysis of the Saccharomyces cerevisiae iron responsive transcription factor Aft1 reveals iron-independent functions. Berthelet S, et al. Genetics, 2010 Jul. PMID 20439772, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables arginine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables arginine-tRNA ligase activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
involved_in arginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in arginyl-tRNA aminoacylation ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in mitochondrial arginyl-tRNA aminoacylation IC
Inferred by Curator
more info
 PubMed 
involved_in mitochondrial translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
arginine--tRNA ligase MSR1
NP_011959.1
  • Mitochondrial arginyl-tRNA synthetase; mutations in human ortholog are associated with pontocerebellar hypoplasia type 6; MSR1 has a paralog, YDR341C, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    284839..286770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179221.1 → NP_011959.1  TPA: arginine--tRNA ligase MSR1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011959.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL43, P38714
    UniProtKB/TrEMBL
    A0A8H4BZL3, A6ZT01, B3LSK9, B5VK21
    Conserved Domains (1) summary
    TIGR00456
    Location:69 → 643
    argS; arginyl-tRNA synthetase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38714.3

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