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TRR2 thioredoxin-disulfide reductase TRR2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856506, updated on 11-Apr-2024

Summary

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Gene symbol
TRR2
Gene description
thioredoxin-disulfide reductase TRR2
Primary source
SGD:S000001148
Locus tag
YHR106W
See related
AllianceGenome:SGD:S000001148
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables thioredoxin-disulfide reductase activity. Involved in cellular response to oxidative stress. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (325598..326626)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) Neighboring gene Ypt35p Neighboring gene septin CDC12 Neighboring gene phosphatidylinositol 4-phosphate-binding protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial and nuclear localization of a novel pea thioredoxin: identification of its mitochondrial target proteins. Martí MC, et al. Plant Physiol, 2009 Jun. PMID 19363090, Free PMC Article
  2. Activation of translation via reduction by thioredoxin-thioredoxin reductase in Saccharomyces cerevisiae. Jun KO, et al. FEBS Lett, 2009 Sep 3. PMID 19622355
  3. Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin. Zhang Z, et al. Biochim Biophys Acta, 2009 Jan. PMID 18930846
  4. Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity. Pedrajas JR, et al. J Biol Chem, 2000 May 26. PMID 10821871
  5. Thioredoxin-dependent peroxide reductase from yeast. Chae HZ, et al. J Biol Chem, 1994 Nov 4. PMID 7961686

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that redox control via the thioredoxin-thioredoxin reductase 1/2 system plays an important role in the regulation of translation.
    Title: Activation of translation via reduction by thioredoxin-thioredoxin reductase in Saccharomyces cerevisiae.
  2. The yeast mitochondrial 1-Cys Prx1 is reactivated by glutathionylation of the catalytic cysteine residue and subsequent reduction by thioredoxin reductase (Trr2) coupled with glutathione (GSH).
    Title: Antioxidant activity of the yeast mitochondrial one-Cys peroxiredoxin is dependent on thioredoxin reductase and glutathione in vivo.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thioredoxin-disulfide reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables thioredoxin-disulfide reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell redox homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in removal of superoxide radicals IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
thioredoxin-disulfide reductase TRR2
NP_011974.1
  • Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    325598..326626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179236.1 → NP_011974.1  TPA: thioredoxin-disulfide reductase TRR2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011974.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL56, P38816
    UniProtKB/TrEMBL
    A0A8H4C261, A6ZT14, B3LSM1, B5VK41, C7GLZ2, C8Z9P9, G2WFI0, N1P2R5
    Conserved Domains (1) summary
    TIGR01292
    Location:28 → 338
    TRX_reduct; thioredoxin-disulfide reductase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38816.1

Gene LinkOut

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