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PCM1 phosphoacetylglucosamine mutase PCM1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856652, updated on 11-Apr-2024

Summary

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Gene symbol
PCM1
Gene description
phosphoacetylglucosamine mutase PCM1
Primary source
SGD:S000000784
Locus tag
YEL058W
See related
AllianceGenome:SGD:S000000784
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
AGM1
Summary
Enables phosphoacetylglucosamine mutase activity. Involved in fungal-type cell wall chitin biosynthetic process. Located in cytoplasm and nucleus. Used to study cancer. Human ortholog(s) of this gene implicated in immunodeficiency 23 and teratoma. Orthologous to human PGM3 (phosphoglucomutase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (43252..44925)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Som1p Neighboring gene Hhy1p Neighboring gene Sdd1p Neighboring gene Hat2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the essential yeast gene encoding N-acetylglucosamine-phosphate mutase. Hofmann M, et al. Eur J Biochem, 1994 Apr 15. PMID 8174553
  2. Functional cloning and mutational analysis of the human cDNA for phosphoacetylglucosamine mutase: identification of the amino acid residues essential for the catalysis. Mio T, et al. Biochim Biophys Acta, 2000 Jul 24. PMID 11004509
  3. Saccharomyces cerevisiae GNA1, an essential gene encoding a novel acetyltransferase involved in UDP-N-acetylglucosamine synthesis. Mio T, et al. J Biol Chem, 1999 Jan 1. PMID 9867860
  4. Increased phosphoglucomutase activity suppresses the galactose growth defect associated with elevated levels of Ras signaling in S. cerevisiae. Howard SC, et al. Curr Genet, 2006 Jan. PMID 16292676
  5. A genetic screen reveals a role for the late G1-specific transcription factor Swi4p in diverse cellular functions including cytokinesis. Igual JC, et al. J Cell Sci, 1997 Jul. PMID 9247198

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables intramolecular phosphotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoacetylglucosamine mutase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoacetylglucosamine mutase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoacetylglucosamine mutase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in UDP-N-acetylglucosamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in fungal-type cell wall chitin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fungal-type cell wall chitin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphoacetylglucosamine mutase PCM1
NP_010856.1
  • Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    43252..44925
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178873.1 → NP_010856.1  TPA: phosphoacetylglucosamine mutase PCM1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010856.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLJ2, P38628
    UniProtKB/TrEMBL
    A0A8H8ULF7, A6ZQP3, G2WCH6, N1P720
    Conserved Domains (1) summary
    cd03086
    Location:24 → 553
    PGM3; PGM3 (phosphoglucomutase 3), also known as PAGM (phosphoacetylglucosamine mutase) and AGM1 (N-acetylglucosamine-phosphate mutase), is an essential enzyme found in eukaryotes that reversibly catalyzes the conversion of GlcNAc-6-phosphate into ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38628.2

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