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FRD1 fumarate reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 856664, updated on 5-May-2024

Summary

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Gene symbol
FRD1
Gene description
fumarate reductase
Primary source
SGD:S000000773
Locus tag
YEL047C
See related
AllianceGenome:SGD:S000000773
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables fumarate reductase (NADH) activity. Involved in cellular response to anoxia. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (65385..66797, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene seripauperin PAU2 Neighboring gene Tca17p Neighboring gene threonine aldolase GLY1 Neighboring gene Ies6p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and sequencing of the gene encoding the soluble fumarate reductase from Saccharomyces cerevisiae. Enomoto K, et al. DNA Res, 1996 Aug 31. PMID 8946166
  2. Role of the AFRD1-encoded fumarate reductase in hypoxia and osmotolerance in Arxula adeninivorans. Sędzielewska KA, et al. FEMS Yeast Res, 2012 Dec. PMID 22900669
  3. GiFRD encodes a protein involved in anaerobic growth in the arbuscular mycorrhizal fungus Glomus intraradices. Sędzielewska KA, et al. Fungal Genet Biol, 2012 Apr. PMID 22343635
  4. Role in anaerobiosis of the isoenzymes for Saccharomyces cerevisiae fumarate reductase encoded by OSM1 and FRDS1. Camarasa C, et al. Yeast, 2007 May. PMID 17345583
  5. Effect of gene disruptions of the TCA cycle on production of succinic acid in Saccharomyces cerevisiae. Arikawa Y, et al. J Biosci Bioeng, 1999. PMID 16232421

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables fumarate reductase (NADH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables fumarate reductase (NADH) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to anoxia IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
fumarate reductase
NP_010867.3
  • Soluble fumarate reductase; required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to Arxula adeninovorans fumarate reductase; protein abundance increases in response to DNA replication stress; FRD1 has a paralog, OSM1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    65385..66797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178862.3 → NP_010867.3  TPA: fumarate reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010867.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLK3, P32614
    UniProtKB/TrEMBL
    A0A8H8ULG8, A6ZQQ4, B3LRX0, B5VH88, C7GKE9, C8Z6U7, G2WCI7, N1PA70
    Conserved Domains (1) summary
    TIGR01813
    Location:5 → 463
    flavo_cyto_c; flavocytochrome c
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32614.1

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