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NPP2 nucleotide diphosphatase/phosphodiesterase NPP2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856699, updated on 4-Jan-2025

Summary

Official Symbol
NPP2
Official Full Name
nucleotide diphosphatase/phosphodiesterase NPP2
Primary source
SGD:S000000742
Locus tag
YEL016C
See related
AllianceGenome:SGD:S000000742; FungiDB:YEL016C; VEuPathDB:YEL016C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables nucleoside triphosphate diphosphatase activity and ribonucleoside triphosphate phosphatase activity. Involved in nucleoside triphosphate metabolic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to several human genes including ENPP4 (ectonucleotide pyrophosphatase/phosphodiesterase 4) and ENPP5 (ectonucleotide pyrophosphatase/phosphodiesterase family member 5). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See NPP2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (124737..126218, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene proteolipid ATPase Neighboring gene Gtt3p Neighboring gene Edc3p Neighboring gene uncharacterized protein

Interactions

General gene information

Gene Ontology Provided by SGD

Component Evidence Code Pubs
located_in endoplasmic reticulum PubMed 
located_in membrane  

General protein information

Preferred Names
nucleotide diphosphatase/phosphodiesterase NPP2
NP_010900.1
  • Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; involved in spore wall assembly; SWAT-GFP and mCherry fusion proteins localize to the endoplasmic reticulum; NPP2 has a paralog, NPP1, that arose from the whole genome duplication; npp1 npp2 double mutant exhibits reduced dityrosine fluorescence relative to single mutants

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    124737..126218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178831.1NP_010900.1  TPA: nucleotide diphosphatase/phosphodiesterase NPP2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010900.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLN4, P39997, Q6B2P3
    UniProtKB/TrEMBL
    B3LS01, C7GX28, N1P5D2
    Conserved Domains (1) summary
    COG1524
    Location:43479
    Npp1; Predicted pyrophosphatase or phosphodiesterase, AlkP superfamily [General function prediction only]
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