PIC2 Cu/Pi carrier [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: PIC2
Gene description: Cu/Pi carrier
Primary source: SGD:S000000855
Locus tag: YER053C
See related: AllianceGenome:SGD:S000000855
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables copper ion transmembrane transporter activity and inorganic phosphate transmembrane transporter activity. Involved in cellular copper ion homeostasis; copper ion transmembrane transport; and phosphate ion transmembrane transport. Located in mitochondrion. Used to study mitochondrial metabolism disease. Orthologous to human SLC25A3 (solute carrier family 25 member 3). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Getting out what you put in: Copper in mitochondria and its impacts on human disease.
Title: Getting out what you put in: Copper in mitochondria and its impacts on human disease.
Phosphate carrier (PiC) can be sorted to either the TIM22 pathway or the TIM23 pathway for its import into yeast mitochondria
Title: The phosphate carrier has an ability to be sorted to either the TIM22 pathway or the TIM23 pathway for its import into yeast mitochondria.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables copper ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in copper ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular copper ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial phosphate ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in phosphate ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

NP_010973.3

Mitochondrial copper and phosphate carrier; imports copper and inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature