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ICL1 isocitrate lyase 1 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856794, updated on 11-Apr-2024

Summary

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Gene symbol
ICL1
Gene description
isocitrate lyase 1
Primary source
SGD:S000000867
Locus tag
YER065C
See related
AllianceGenome:SGD:S000000867
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables isocitrate lyase activity. Involved in glyoxylate cycle. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
1
Sequence:
Chromosome: V; NC_001137.3 (285241..286914, complement)

Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Tho1p Neighboring gene Vhr2p Neighboring gene tRNA-Ser Neighboring gene Rrt13p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural insights into the targeting specificity of ubiquitin ligase for S. cerevisiae isocitrate lyase but not C. albicans isocitrate lyase. Hiragi K, et al. J Struct Biol, 2021 Sep. PMID 34033899
  2. Isocitrate lyase of the yeast Kluyveromyces lactis is subject to glucose repression but not to catabolite inactivation. López ML, et al. Curr Genet, 2004 Jan. PMID 14569415
  3. The purification and properties of yeast isocitric lyase. OLSON JA. J Biol Chem, 1959 Jan. PMID 13610881
  4. PTS1-independent targeting of isocitrate lyase to peroxisomes requires the PTS1 receptor Pex5p. Parkes JA, et al. Mol Membr Biol, 2003 Jan-Mar. PMID 12745927
  5. A 27 kDa protein binds to a positive and a negative regulatory sequence in the promoter of the ICL1 gene from Saccharomyces cerevisiae. Ordiz I, et al. Biochem J, 1998 Jan 15. PMID 9425123, Free PMC Article

See all (70) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables isocitrate lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isocitrate lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables isocitrate lyase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylisocitrate lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glyoxylate cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in glyoxylate cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monocarboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
isocitrate lyase 1
NP_010987.3
  • Isocitrate lyase; catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001137.3 Reference assembly

    Range
    285241..286914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001178956.3 → NP_010987.3  TPA: isocitrate lyase 1 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_010987.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DLX0, P28240
    UniProtKB/TrEMBL
    A0A8H8ULT2, A6ZR19, B3LRI2, C7GTD3, C8Z771, G2WCV4
    Conserved Domains (1) summary
    pfam00463
    Location:22 → 550
    ICL; Isocitrate lyase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28240.1

Gene LinkOut

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