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argH argininosuccinate lyase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885365, updated on 11-Dec-2020

Summary

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Gene symbol
argH
Gene description
argininosuccinate lyase
Locus tag
Rv1659
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
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Genomic context

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Sequence:
NC_000962.3 (1872639..1874051)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene ornithine carbamoyltransferase Neighboring gene arginine repressor Neighboring gene argininosuccinate synthase Neighboring gene chalcone synthase Neighboring gene polyketide synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structure and biochemical study on argininosuccinate lyase from Mycobacterium tuberculosis. Chen X, et al. Biochem Biophys Res Commun, 2019 Feb 26. PMID 30665717
  2. Biochemical characterization of argininosuccinate lyase from M. tuberculosis: significance of a c-terminal cysteine in catalysis and thermal stability. Mishra A, et al. IUBMB Life, 2017 Nov. PMID 29044950
  3. Cloning, expression, purification, crystallization and preliminary X-ray studies of argininosuccinate lyase (Rv1659) from Mycobacterium tuberculosis. Paul A, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Dec. PMID 24316845, Free PMC Article
  4. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  5. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A major conformational change in the MtbASL-SO4 complex structure could be observed upon sulfate binding, and this movement facilitates the interaction between substrate and the residues involved in catalysis. A different conformational change in the C-terminal domain could be observed in the MtbASL-SO4 complex compared with that in other homologues.
    Title: Crystal structure and biochemical study on argininosuccinate lyase from Mycobacterium tuberculosis.
  2. Significance of a C-terminal cysteine of argininosuccinate lyase from M. tuberculosis for biocatalysis has been demonstrated.
    Title: Biochemical characterization of argininosuccinate lyase from M. tuberculosis: significance of a c-terminal cysteine in catalysis and thermal stability.
  3. Mycobacterium tuberculosis ArgH is a tetrameric enzyme with a subunit molecular weight of 50.9 kDa.
    Title: Cloning, expression, purification, crystallization and preliminary X-ray studies of argininosuccinate lyase (Rv1659) from Mycobacterium tuberculosis.
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Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
argininosuccinate lyase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    1872639..1874051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216175.1 argininosuccinate lyase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216175.1

    Status: PROVISIONAL

    Conserved Domains (1) summary
    TIGR00838
    Location:8 → 465
    argH; argininosuccinate lyase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6IEM_A.1
6IEM_B.1
6IEM_C.1
6IEM_D.1
6IEM_E.1
6IEM_F.1
6IEM_G.1
6IEM_H.1
6IEN_A.1
6IEN_B.1
6IEN_C.1
6IEN_D.1
6IG5_A.1
6IG5_B.1
6IG5_C.1
6IG5_D.1
6IGA_A.1
6IGA_B.1
6IGA_C.1
6IGA_D.1
P9WPY7.1

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