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aceAb isocitrate lyase AceAb [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885383, updated on 6-Oct-2023

Summary

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Gene symbol
aceAb
Gene description
isocitrate lyase AceAb
Locus tag
Rv1916
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
icl2b
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Genomic context

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Sequence:
NC_000962.3 (2161566..2162762)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene oxidoreductase FadB Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene isocitrate lyase AceAa Neighboring gene PPE family protein PPE34 Neighboring gene PPE family protein PPE35

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis. Pham TV, et al. Proc Natl Acad Sci U S A, 2017 Jul 18. PMID 28679637, Free PMC Article
  2. Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis. Nandakumar M, et al. Nat Commun, 2014 Jun 30. PMID 24978671
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. 2-vinyl-d-isocitrate (2-VIC) is a mechanism-based inactivator of Mycobacterium tuberculosis ICL1 and ICL2
    Title: Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis.
  2. Icl1 and icl2 mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
    Title: Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

General protein information

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Preferred Names
isocitrate lyase AceAb

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2161566..2162762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216432.1 isocitrate lyase AceAb [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216432.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4LVU9
    Conserved Domains (1) summary
    cl21457
    Location:55 → 232
    TIM; TIM-like beta/alpha barrel domains
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O07717.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases