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Rv1885c chorismate mutase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 885772, updated on 1-Apr-2024

Summary

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Gene symbol
Rv1885c
Gene description
chorismate mutase
Locus tag
Rv1885c
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
*MtCM
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Genomic context

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Sequence:
NC_000962.3 (2134273..2134872, complement)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene resuscitation-promoting factor RpfC Neighboring gene diacylglycerol acyltransferase/mycolyltransferase Ag85B Neighboring gene hypothetical protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Complex Formation between Two Biosynthetic Enzymes Modifies the Allosteric Regulatory Properties of Both: AN EXAMPLE OF MOLECULAR SYMBIOSIS. Blackmore NJ, et al. J Biol Chem, 2015 Jul 17. PMID 26032422, Free PMC Article
  2. Molecular dynamics simulation of the last step of a catalytic cycle: product release from the active site of the enzyme chorismate mutase from Mycobacterium tuberculosis. Choutko A, et al. Protein Sci, 2012 Nov. PMID 22898919, Free PMC Article
  3. Biochemical and structural characterization of the secreted chorismate mutase (Rv1885c) from Mycobacterium tuberculosis H37Rv: an *AroQ enzyme not regulated by the aromatic amino acids. Kim SK, et al. J Bacteriol, 2006 Dec. PMID 17146044, Free PMC Article
  4. The 2.15 A crystal structure of Mycobacterium tuberculosis chorismate mutase reveals an unexpected gene duplication and suggests a role in host-pathogen interactions. Qamra R, et al. Biochemistry, 2006 Jun 13. PMID 16752890
  5. Preliminary X-ray crystallographic analysis of the secreted chorismate mutase from Mycobacterium tuberculosis: a tricky crystallization problem solved. Krengel U, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 May 1. PMID 16682771, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A secreted form of chorismate mutase (Rv1885c) in Mycobacterium bovis BCG contributes to pathogenesis by inhibiting mitochondria-mediated apoptotic cell death of macrophages.
    Title: A secreted form of chorismate mutase (Rv1885c) in Mycobacterium bovis BCG contributes to pathogenesis by inhibiting mitochondria-mediated apoptotic cell death of macrophages.
  2. DAH7PS and chorismate mutase provide exquisite control of aromatic amino acid biosynthesis, not only controlling flux into the start of the pathway, but also directing the pathway intermediate chorismate into either Phe/Tyr or Trp biosynthesis.
    Title: Complex Formation between Two Biosynthetic Enzymes Modifies the Allosteric Regulatory Properties of Both: AN EXAMPLE OF MOLECULAR SYMBIOSIS.
  3. Studied the product release from the active site of the Mycobacterium tuberculosis chorismate mutase using molecular dynamics simulation.
    Title: Molecular dynamics simulation of the last step of a catalytic cycle: product release from the active site of the enzyme chorismate mutase from Mycobacterium tuberculosis.
  4. Genes from M. tuberculosis are constitutively expressed or subjected to minor regulation by aromatic amino acids levels, especially tryptophan.
    Title: The two chorismate mutases from both Mycobacterium tuberculosis and Mycobacterium smegmatis: biochemical analysis and limited regulation of promoter activity by aromatic amino acids.
  5. Secreted chorismate mutase from Mycobacterium tuberculosis a 37.2 kDa dimeric protein belonging to AroQ(gamma) subclass of mutases, crystallized. Asymmetric unit contains 1 biological dimer, with 167 amino acids per protomer.
    Title: Preliminary X-ray crystallographic analysis of the secreted chorismate mutase from Mycobacterium tuberculosis: a tricky crystallization problem solved.
  6. The Rv1885c-encoded chorismate mutase showed allosteric regulation by pathway-specific as well as cross-pathway-specific ligands, as evident from proteolytic cleavage protection and enzyme assays.
    Title: Purified recombinant hypothetical protein coded by open reading frame Rv1885c of Mycobacterium tuberculosis exhibits a monofunctional AroQ class of periplasmic chorismate mutase activity.
  7. chorismate mutase might have a role to play in host-pathogen interactions, making it an important target for designing inhibitor molecules against the deadly pathogen
    Title: The 2.15 A crystal structure of Mycobacterium tuberculosis chorismate mutase reveals an unexpected gene duplication and suggests a role in host-pathogen interactions.
  8. Our investigation on the effect of phenylalanine, tyrosine, and tryptophan on *chorismate mutase (MtCM) shows that MtCM is not regulated by the aromatic amino acids. The X-ray structure of MtCM does not have an allosteric regulatory site. [MtCM]
    Title: Biochemical and structural characterization of the secreted chorismate mutase (Rv1885c) from Mycobacterium tuberculosis H37Rv: an *AroQ enzyme not regulated by the aromatic amino acids.
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General gene information

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Homology

General protein information

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Preferred Names
chorismate mutase
NP_216401.1
  • chorismate mutase, AroQ class; secreted, possible role in host-pathogen interactions

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    2134273..2134872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_216401.1 chorismate mutase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_216401.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    R4M6G0
    Conserved Domains (1) summary
    PRK09269
    Location:6 → 198
    PRK09269; chorismate mutase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WIB9.1

Gene LinkOut

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Molecular Biology Databases
Research Materials