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icl1 isocitrate lyase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886291, updated on 6-Oct-2023

Summary

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Gene symbol
icl1
Gene description
isocitrate lyase
Locus tag
Rv0467
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
aceA; icl
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Genomic context

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Sequence:
NC_000962.3 (557527..558813)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene HTH-type transcriptional regulator Neighboring gene hypothetical protein Neighboring gene 3-hydroxybutyryl-CoA dehydrogenase Neighboring gene mycolic acid synthase UmaA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Demystifying the catalytic pathway of Mycobacterium tuberculosis isocitrate lyase. Ibeji CU, et al. Sci Rep, 2020 Nov 3. PMID 33144641, Free PMC Article
  2. Activity loss by H46A mutation in Mycobacterium tuberculosis isocitrate lyase is due to decrease in structural plasticity and collective motions of the active site. Shukla R, et al. Tuberculosis (Edinb), 2018 Jan. PMID 29523315
  3. Identification of a novel inhibitor of isocitrate lyase as a potent antitubercular agent against both active and non-replicating Mycobacterium tuberculosis. Liu Y, et al. Tuberculosis (Edinb), 2016 Mar. PMID 26980494
  4. ¹³C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation. Beste DJ, et al. PLoS Pathog, 2011 Jul. PMID 21814509, Free PMC Article
  5. Mycobacterium tuberculosis isocitrate lyase (MtbIcl): role of divalent cations in modulation of functional and structural properties. Kumar R, et al. Proteins, 2008 Aug 15. PMID 18275086

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Demystifying the catalytic pathway of Mycobacterium tuberculosis isocitrate lyase.
    Title: Demystifying the catalytic pathway of Mycobacterium tuberculosis isocitrate lyase.
  2. H46A mutation in Mycobacterium tuberculosis isocitrate lyase results in activity loss due to decrease in structural plasticity and collective motions of the active site.
    Title: Activity loss by H46A mutation in Mycobacterium tuberculosis isocitrate lyase is due to decrease in structural plasticity and collective motions of the active site.
  3. 2-vinyl-d-isocitrate (2-VIC) is a mechanism-based inactivator of Mycobacterium tuberculosis ICL1 and ICL2
    Title: Mechanism-based inactivator of isocitrate lyases 1 and 2 from Mycobacterium tuberculosis.
  4. Isocitrate lyase inhibitors were active in both log-phase M. tuberculosis in vitro and dormant M. tuberculosis in macrophages.
    Title: Identification of a novel inhibitor of isocitrate lyase as a potent antitubercular agent against both active and non-replicating Mycobacterium tuberculosis.
  5. Icl1 and icl2 mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
    Title: Isocitrate lyase mediates broad antibiotic tolerance in Mycobacterium tuberculosis.
  6. (1)(3)C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation.
    Title: ¹³C metabolic flux analysis identifies an unusual route for pyruvate dissimilation in mycobacteria which requires isocitrate lyase and carbon dioxide fixation.
  7. Data revealed that the Rv0465c protein, now designated RamB, represses icl1 expression during growth with glucose and negatively autoregulates the expression of its own operon.
    Title: Role of the transcriptional regulator RamB (Rv0465c) in the control of the glyoxylate cycle in Mycobacterium tuberculosis.
  8. The results obtained from the studies provide intriguing insight into the possible mechanism of divalent cation-induced changes in structure, function, and stability of MtbIcl.
    Title: Mycobacterium tuberculosis isocitrate lyase (MtbIcl): role of divalent cations in modulation of functional and structural properties.
  9. study provides enzymatic evidence that shows that despite the absence of the 2-methylisocitrate lyase signature, ICL1 can clearly function as a methylcitrate lyase
    Title: Dual role of isocitrate lyase 1 in the glyoxylate and methylcitrate cycles in Mycobacterium tuberculosis.
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General gene information

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Homology

General protein information

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Preferred Names
isocitrate lyase
YP_177728.1
  • Icl (isocitrase) (isocitratase)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    557527..558813
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    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_177728.1 isocitrate lyase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for YP_177728.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A655I828
    Conserved Domains (1) summary
    PRK15063
    Location:2 → 428
    PRK15063; isocitrate lyase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6XPP_A.1
6XPP_B.1
6XPP_C.1
6XPP_D.1
P9WKK7.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases