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rmlA glucose-1-phosphate thymidylyltransferase [ Mycobacterium tuberculosis H37Rv ]

Gene ID: 886568, updated on 6-Oct-2023

Summary

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Gene symbol
rmlA
Gene description
glucose-1-phosphate thymidylyltransferase
Locus tag
Rv0334
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
Lineage
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
Also known as
rfbA
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Genomic context

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Sequence:
NC_000962.3 (398658..399524)

NC_000962.3Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene PE family protein PE6 Neighboring gene hypothetical protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000962.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes. Brown HA, et al. Protein Sci, 2018 Feb. PMID 29076563, Free PMC Article
  2. An rmlA gene encoding d-glucose-1-phosphate thymidylyltransferase is essential for mycobacterial growth. Qu H, et al. FEMS Microbiol Lett, 2007 Oct. PMID 17784859
  3. TubercuList--10 years after. Lew JM, et al. Tuberculosis (Edinb), 2011 Jan. PMID 20980199
  4. Re-annotation of the genome sequence of Mycobacterium tuberculosis H37Rv. Camus JC, et al. Microbiology (Reading), 2002 Oct. PMID 12368430
  5. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Cole ST, et al. Nature, 1998 Jun 11. PMID 9634230

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study reports a functional and structural investigation of RmlA in complex with either dTTP or dTDP-glucose. In the RmlA/dTTP complex, two magnesium ions were observed binding to the nucleotide, while in the RmlA/dTDP-glucose complex, only one magnesium ion is. This represents the first observation of the manner in which a magnesium ion is coordinated to the RmlA product which is important for structure-based drug design.
    Title: The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes.
  2. The results demonstrate that the rmlA gene is essential for mycobacterial growth and that lack of RmlA activity has profound negative effects on bacterial cell morphology.
    Title: An rmlA gene encoding d-glucose-1-phosphate thymidylyltransferase is essential for mycobacterial growth.
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General gene information

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Homology

General protein information

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Preferred Names
glucose-1-phosphate thymidylyltransferase
NP_214848.1
  • alpha-D-glucose-1-phosphate thymidylyltransferase RmlA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000962.3 Reference assembly

    Range
    398658..399524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_214848.1 glucose-1-phosphate thymidylyltransferase [Mycobacterium tuberculosis H37Rv]

    See identical proteins and their annotated locations for NP_214848.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A655AE50
    Conserved Domains (1) summary
    TIGR01207
    Location:2 → 286
    rmlA; glucose-1-phosphate thymidylyltransferase, short form
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P9WH13.1

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